N-Acetyl-L-leucine ethyl ester

Base Information

• Chemical Name: N-Acetyl-L-leucine ethyl ester
• CAS No.: 4071-36-7
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.266
• Hs Code.: 2924199090
• Mol file: 4071-36-7.mol

Synonyms:N-ACETYL-L-LEUCINE ETHYL ESTER;

Chemical Property of N-Acetyl-L-leucine ethyl ester

Chemical Property:

• PSA: 58.89000
• LogP: 1.94060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Ethyl2-Acetamido-4-methylpentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetyl-L-leucine ethyl ester

There total 7 articles about N-Acetyl-L-leucine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + N-acetylleucine (99-15-0) → ethyl N-acetyl-leucinate (4071-36-7)

Guidance literature:

DOI:10.1021/ja01160a054

Reference yield:

DL-leucine ethyl ester (2899-43-6,75023-21-1) + acetic anhydride (108-24-7) → ethyl N-acetyl-leucinate (4071-36-7)

Guidance literature:

With sodium acetate; acetyl-l-leucine ethyl ester; auf dem Wasserbad;

Reference yield:

DL-leucine methyl ester (18869-43-7) → ethyl N-acetyl-leucinate (4071-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOCH₃ / Brenner esterification

2: pyridine

With pyridine; sodium methylate;

DOI:10.1016/S0040-4020(01)90011-0

upstream raw materials:

ethanol

N-acetylleucine

LEUCINE

acetylamino-isobutyl-malonic acid monoethyl ester

Downstream raw materials:

N-acetyl-N'-methylleucinamide

N-Acetyl-L-leucin-ethylester

N-acetyl-O-ethyl-D-leucine

N-Ac-Leu

Refernces

• 1、 Glaenzer, B. I.,Faber, K.,Griengl, H.. "ENANTIOSELECTIVE HYDROLYSIS BY BAKER'S YEAST - II. ESTERS OF N-ACETYL AMINO ACIDS". . p. 771 - 778. Retrieved 2007/10/02.