22DIETHYL11BIPHENYL

Base Information

• Chemical Name: 22DIETHYL11BIPHENYL
• CAS No.: 13049-35-9
• Molecular Formula: C16H18
• Molecular Weight: 210.319
• Hs Code.: 2902909090
• Mol file: 13049-35-9.mol

Synonyms:Biphenyl,2,2'-diethyl- (6CI,7CI,8CI); 2,2'-Diethyl-1,1'-biphenyl; 2,2'-Diethylbiphenyl

Chemical Property of 22DIETHYL11BIPHENYL

Chemical Property:

• Vapor Pressure: 0.000226mmHg at 25°C
• Boiling Point: 336°Cat760mmHg
• Flash Point: 165.9°C
• PSA: 0.00000
• Density: 0.954g/cm³
• LogP: 4.47840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 22DIETHYL11BIPHENYL

There total 3 articles about 22DIETHYL11BIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-ethylphenyl boronic acid (90002-36-1) + 2-chloro-1,3-bis(1-methylethyl)benzene (54845-36-2) → 1,3-diisopropylbenzene (99-62-7) + 1,1'-Biphenyl, 2,2'-diethyl (13049-35-9) + 2,6-diisopropyl-2'-ethylbiphenyl (1482498-19-0)

Guidance literature:

With potassium phosphate monohydrate; Ethyl 4-bromobenzoate; C₅₂H₄₉PRu; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo402089r

Reference yield:

2,6-diisopropylbenzenamine (24544-04-5) → 1,3-diisopropylbenzene (99-62-7) + 1,1'-Biphenyl, 2,2'-diethyl (13049-35-9) + 2,6-diisopropyl-2'-ethylbiphenyl (1482498-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water; ethanol / 1 h / 0 °C / Inert atmosphere

1.2: 0.83 h / Inert atmosphere; Reflux

2.1: C₅₂H₄₉PRu; potassium phosphate monohydrate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; Ethyl 4-bromobenzoate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate monohydrate; Ethyl 4-bromobenzoate; C₅₂H₄₉PRu; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium nitrite; In 1,4-dioxane; ethanol; water; 2.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/jo402089r

Reference yield:

ethylbenzene (100-41-4,27536-89-6) → 4,4'-diethylbiphenyl (13049-40-6) + 3,3'-diethyl-1,1'-biphenyl (13049-38-2) + 1,1'-Biphenyl, 2,2'-diethyl (13049-35-9) + 3,4’-diethyl-1,1’-biphenyl (13049-39-3) + 4,2'-Diaethyl-biphenyl (13049-37-1) + 2,3'-diethyl-1,1'-biphenyl (13049-36-0)

Guidance literature:

With thallium(III) trifluoroacetate; palladium diacetate; at 70 ℃; for 20h; Product distribution; variation of amount of Pd(II) and temperature;

DOI:10.1016/S0040-4020(01)91964-7

upstream raw materials:

ethylbenzene

2-ethylphenyl boronic acid

2-chloro-1,3-bis(1-methylethyl)benzene

2,6-diisopropylbenzenamine

Refernces

• 1、 Yatsimirsky, Anatoly K.,Deiko, Sergei A.,Ryabov, Alexander D.. "PALLADIUM(II)-CATALYZED OXIDATIVE COUPLING OF ARENES BY THALLIUM(III)". . p. 2381 - 2392. Retrieved 2007/10/02.