2-amino-1-(3-bromophenyl)ethan-1-ol

Base Information

• Chemical Name: 2-amino-1-(3-bromophenyl)ethan-1-ol
• CAS No.: 41147-81-3
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.077
• Hs Code.: 2922199090
• Mol file: 41147-81-3.mol

Synonyms:2-(3-bromophenyl)-2-hydroxyethanamine;2-amino-1-(3-bromo-phenyl)-ethanol;2-hydroxy-2-(3-bromophenyl) ethanamine;DL-[2-(3-bromophenyl)-2-hydroxyethyl]amine;2-amino-1-(3-bromophenyl)ethan-1-ol;

Chemical Property of 2-amino-1-(3-bromophenyl)ethan-1-ol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 341.645oC at 760 mmHg
• Flash Point: 160.421oC
• PSA: 46.25000
• Density: 1.539g/cm3
• LogP: 2.14150

Purity/Quality:

98%min ^*data from raw suppliers

BENZENEMETHANOL,α-(AMINOMETHYL)-3-BROMO- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-1-(3-bromophenyl)ethan-1-ol

There total 9 articles about 2-amino-1-(3-bromophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-azido-1-(3-bromophenyl)ethanol (943911-72-6) → DL-[2-(3-bromophenyl)-2-hydroxyethyl]amine (41147-81-3)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

1-(3-bromophenyl)-2-nitroethanol (39220-96-7) → DL-[2-(3-bromophenyl)-2-hydroxyethyl]amine (41147-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / CH₂Cl₂

2: H₂ / Raney nickel / methanol

3: Bu₄NF / tetrahydrofuran

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; nickel; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.11.041

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) + trimethylsilyl cyanide (7677-24-9) → DL-[2-(3-bromophenyl)-2-hydroxyethyl]amine (41147-81-3)

Guidance literature:

m-bromobenzoic aldehyde; trimethylsilyl cyanide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 50h; Reflux;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

With water; silica gel; sodium sulfate; In tetrahydrofuran; ethyl acetate; at 20 ℃;

upstream raw materials:

m-bromobenzoic aldehyde

1-(3-bromophenyl)-2-nitroethanol

2-azido-1-(3-bromophenyl)ethanol

trimethylsilyl cyanide

Downstream raw materials:

5-(3-bromophenyl)oxazolidin-2-one

Refernces

• 1、 Ghosh, Priya,Deka, Manash J.,Saikia, Anil K.. "Lewis acid mediated intramolecular C-O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: Total synthesis of (±)-Viloxazine". . p. 690 - 698. Retrieved 2016/01/15.
• 2、 Wittman, Mark D.,Balasubramanian, Balu,Stoffan, Karen,Velaparthi, Upender,Liu, Pieying,Krishnanathan, Subramaniam,Carboni, Joan,Li, Aixin,Greer, Ann,Attar, Ricardo,Gottardis, Marco,Chang, Chiehying,Jacobson, Bruce,Sun, Yax,Hansel, Steven,Zoeckler, Mary,Vyas, Dolatrai M.. "Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase". . p. 974 - 977. Retrieved 2007/10/03.