4-Piperidinone, 2-(4-fluoro-2-methylphenyl)-, (2R)-

Base Information

• Chemical Name: 4-Piperidinone, 2-(4-fluoro-2-methylphenyl)-, (2R)-
• CAS No.: 414910-12-6
• Molecular Formula: C12H14FNO
• Molecular Weight: 207.248

Synonyms:(R)-2-(4-Fluoro-2-methyl-phenyl)-piperidin-4-one;(2R)-2-(4-fluoro-2-methylphenyl)-4-oxo-1-piperidine;2-(R)-(4-fluoro-2-methyl-phenyl)-piperidin-4-one;

Chemical Property of 4-Piperidinone, 2-(4-fluoro-2-methylphenyl)-, (2R)-

Chemical Property:

• Boiling Point: 326.7±42.0 °C(Predicted)
• PSA: 29.10000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 2.45650

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinone, 2-(4-fluoro-2-methylphenyl)-, (2R)-

There total 6 articles about 4-Piperidinone, 2-(4-fluoro-2-methylphenyl)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone-1-carboxylate (717920-53-1) → (2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone (414910-12-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h; under 760 Torr;

DOI:10.1021/ja048825m

Reference yield:

2-(R)-(4-fluoro-2-methyl-phenyl)-2,3-dihydro-1H-pyridin-4-one (414910-11-5) → (2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone (414910-12-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; under 1520.1 Torr; Pressure reactor;

Reference yield:

(2R)-2-(4-fluoro-2-methylphenyl)-4-oxo-1-piperidine L(-)mandelate (935534-58-0) → (2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone (414910-12-6)

Guidance literature:

With sodium carbonate; In water; ethyl acetate; at 20 - 25 ℃;

upstream raw materials:

(R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone-1-carboxylate

benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate

(2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone L-(+)-mandelate

2-(R)-(4-fluoro-2-methyl-phenyl)-2,3-dihydro-1H-pyridin-4-one

Downstream raw materials:

(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

methyl (2Z,2E)-4-[(2R,4S)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-({[(phenylmethyl)oxy]carbonyl}amino)-4-piperidinyl]-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-butenoate

(2R,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride

(2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride

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