1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphen yl)-N-methyl-4-oxo-, (2R)-

Base Information

• Chemical Name: 1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphen yl)-N-methyl-4-oxo-, (2R)-
• CAS No.: 414910-03-5
• Molecular Formula: C24H23F7N2O2
• Molecular Weight: 504.448
• Mol file: 414910-03-5.mol

Synonyms:2-(R)-(4-fluoro-2-methyl-phenyl)-4-oxo-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)ethyl]-methylamide;2-(R)-(4-fluoro-2-methylphenyl)-4-oxopiperidine-1-carboxylic acid [1-((R)-3,5-bis-trifluoromethylphenyl)ethyl]methylamide;(2R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)ethyl}-N-methylamino-carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxopiperidine;2-(R)-(4-fluoro-2-methyl-phenyl)-4-oxo-piperidine-1-carboxylic acid [1-(R)-3,5-bis-(trifluoromethyl-phenyl)-ethyl]-methylamide;(2R)-1-{N-(1-(R)-3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4- fluoro-2-methylphenyl)-4-oxopiperidine;

Chemical Property of 1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphen yl)-N-methyl-4-oxo-, (2R)-

Chemical Property:

• PSA: 40.62000
• LogP: 6.62860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphen yl)-N-methyl-4-oxo-, (2R)-

There total 13 articles about 1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphen yl)-N-methyl-4-oxo-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone L-(+)-mandelate (414910-13-7) + bis(trichloromethyl) carbonate (32315-10-9) + (1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine L-malate → (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide (414910-03-5)

Guidance literature:

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine L-malate; With sodium carbonate; In water; ethyl acetate; at 20 ℃; for 0.25h;

(2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone L-(+)-mandelate; With ammonium hydroxide; In water; ethyl acetate; for 0.25h; Inert atmosphere;

bis(trichloromethyl) carbonate; With triethylamine; In ethyl acetate; at 10 ℃; for 5.25h; Reflux; Inert atmosphere;

DOI:10.1021/jm1013264

Reference yield:

2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine (629953-69-1) + [(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl](methyl)amine (334477-60-0) → (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide (414910-03-5)

Guidance literature:

[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl](methyl)amine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 40 ℃;

With methyl iodide; In acetonitrile; at 60 ℃; for 2h;

2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine; With sodium hydroxide; sulfuric acid; water; triethylamine; more than 3 stages;

Reference yield:

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanaminehydrochloride (414910-05-7) + bis(trichloromethyl) carbonate (32315-10-9) + (2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone (414910-12-6) → (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide (414910-03-5)

Guidance literature:

bis(trichloromethyl) carbonate; (2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone; With triethylamine; In ethyl acetate; at 0 - 20 ℃; for 4.66667h;

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanaminehydrochloride; In ethyl acetate; for 16h; Heating / reflux;

upstream raw materials:

2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine

[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl](methyl)amine

2-(4-fluoro-2-methyl-phenyl)-piperidine-4-one

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanaminehydrochloride

Downstream raw materials:

[14C]-Casopitant

2-(R)-(4-fluoro-2-methyl-phenyl)-4-(R)-[(4-tert-butoxycarbonyl)-piperazin-1-yl]-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide

2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-[(4-tert-butoxycarbonyl)-piperazin-1-yl]-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide

C₂₈H₃₁F₇N₄O₂