Carbonic acid, methyl 3-phenyl-2-propynyl ester

Base Information

• Chemical Name: Carbonic acid, methyl 3-phenyl-2-propynyl ester
• CAS No.: 420121-38-6
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Mol file: 420121-38-6.mol

Synonyms:

Chemical Property of Carbonic acid, methyl 3-phenyl-2-propynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid, methyl 3-phenyl-2-propynyl ester

There total 2 articles about Carbonic acid, methyl 3-phenyl-2-propynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-Phenyl-2-propyn-1-ol (1504-58-1) + methyl chloroformate (79-22-1) → methyl (3-phenylprop-2-yn-1-yl) carbonate (420121-38-6)

Guidance literature:

In pyridine; diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jo0111098

Reference yield:

iodobenzene (591-50-4) → methyl (3-phenylprop-2-yn-1-yl) carbonate (420121-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dimethyl sulfoxide / 40 - 45 °C

2: pyridine; dmap / dichloromethane / 2 h / 0 - 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/chem.201100248

Reference yield: 87.0%

methyl (3-phenylprop-2-yn-1-yl) carbonate (420121-38-6) + phenol (108-95-2,27073-41-2) → 2-benzylbenzofuran (4265-14-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); P(p-CH₃OC₆H₄)3; cesium acetate; lithium chloride; In dimethyl sulfoxide; at 100 ℃; for 16h; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.06.023

upstream raw materials:

3-Phenyl-2-propyn-1-ol

methyl chloroformate

iodobenzene

Downstream raw materials:

ethyl 6-phenylhex-5-yn-(2Z)-enoate

ethyl (E)-6-phenylhex-2-en-5-ynoate

phenyl (3-phenylprop-2-yn-1-yl) sulfide

diethyl (1-phenylpropa-1,2-dienyl)phosphonate