1-Methyl-2,3-Pyrrolidinedione

Base Information

• Chemical Name: 1-Methyl-2,3-Pyrrolidinedione
• CAS No.: 42599-26-8
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.11500
• Mol file: 42599-26-8.mol

Synonyms:L-METHYL-2,3-PYRROLIDINEDIONE;1-methyl-pyrrolidine-2,3-dione;1-methyl-2,3-pyrrolidinedione;1-methyl-2,3-pyrrolidindion;

Chemical Property of 1-Methyl-2,3-Pyrrolidinedione

Chemical Property:

• PSA: 37.38000
• LogP: -0.64450

Purity/Quality:

99% ^*data from raw suppliers

1-Methylpyrrolidine-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-2,3-Pyrrolidinedione

There total 5 articles about 1-Methyl-2,3-Pyrrolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-hydroxy-1-methyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid → 1-methylpyrrolidine-2,3-dione (42599-26-8)

Guidance literature:

In tetrahydrofuran; at 65 ℃; for 4h;

Reference yield: 74.0%

3-<(N,N-dimethylamino)methylene>-1-methyl-2-pyrrolidinone (59157-01-6) → 1-methylpyrrolidine-2,3-dione (42599-26-8)

Guidance literature:

With oxygen; rose bengal; In dichloromethane; at -78 ℃; for 1h; Irradiation;

DOI:10.1021/jo00219a025

Reference yield:

4-carbethoxy-2,3-dioxo-1-methylpyrrolidine (5336-42-5) → 1-methylpyrrolidine-2,3-dione (42599-26-8)

Guidance literature:

4-carbethoxy-2,3-dioxo-1-methylpyrrolidine; With hydrogen bromide; In water; acetic acid; for 1h; Reflux;

With sodium hydrogencarbonate; In water; pH=~ 7;

upstream raw materials:

3-<(N,N-dimethylamino)methylene>-1-methyl-2-pyrrolidinone

4-carbethoxy-2,3-dioxo-1-methylpyrrolidine

Downstream raw materials:

(rac)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one

Refernces

• 1、 Bender et al.. "-". . p. 3439. Retrieved 1973.
• 2、 -. "ALKYNYL ALCOHOLS AS KINASE INHIBITORS". Page/Page column 175-176. . Retrieved 2010/01/30.