ethyl 1-Methyl-4,5-dioxopyrrolidine-3-carboxylate

Base Information

• Chemical Name: ethyl 1-Methyl-4,5-dioxopyrrolidine-3-carboxylate
• CAS No.: 5336-42-5
• Molecular Formula: C₈H₁₁NO₄
• Molecular Weight: 185.18
• Hs Code.: 2933990090
• Mol file: 5336-42-5.mol

Synonyms:4-carbethoxy-2,3-dioxo-1-methylpyrrolidine;1-methyl-4,5-dioxo-pyrrolidine-3-carboxylic acid ethyl ester;1-METHYL-4,ETHYL ESTER;ethyl 1-methyl-4,5-dioxo-3-pyrrolidinecarboxylate;1-Methyl-4,5-dioxo-pyrrolidin-3-carbonsaeure-aethylester;

Chemical Property of ethyl 1-Methyl-4,5-dioxopyrrolidine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.00769mmHg at 25°C
• Boiling Point: 268.4°Cat760mmHg
• PKA: 7.93±0.20(Predicted)
• Flash Point: 116.1°C
• PSA: 63.68000
• Density: 1.26g/cm³
• LogP: -0.85530

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Ethyl 1-methyl-4,5-dioxo-3-pyrrolidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1-Methyl-4,5-dioxopyrrolidine-3-carboxylate

There total 1 articles about ethyl 1-Methyl-4,5-dioxopyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylamine (74-89-5) + ethyl acrylate (140-88-5,9003-32-1) → 4-carbethoxy-2,3-dioxo-1-methylpyrrolidine (5336-42-5)

Guidance literature:

With ethanol; Erwaermen des Reaktionsgemisches mit Oxalsaeure-diaethylester und aethanol. Natriumaethylat;

DOI:10.1021/jo01116a009

Reference yield: 72.0%

4-carbethoxy-2,3-dioxo-1-methylpyrrolidine (5336-42-5) + 4-aminophenyl phenyl sulfide (1135-14-4) → 1-Methyl-5-oxo-4-(4-phenylsulfanyl-phenylamino)-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester (77711-87-6)

Guidance literature:

In ethanol; for 48h; Heating;

DOI:10.1021/jm00139a025

Reference yield: 70.0%

4-carbethoxy-2,3-dioxo-1-methylpyrrolidine (5336-42-5) + 3,5-diamino-4-(p-chlorophenylazo)pyrazole (3656-04-0) → 2-amino-3-(4-chloro-phenylazo)-7-methyl-6,7-dihydro-4H-1,4,7,8b-tetraaza-as-indacene-5,8-dione

Guidance literature:

With acetic acid; for 3h; Heating;

DOI:10.1002/jccs.200200151

upstream raw materials:

methylamine

ethyl acrylate

Downstream raw materials:

1-Methyl-5-oxo-4-(4-phenylsulfanyl-phenylamino)-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

N-methyl-N-[(4-phenylthio)phenyl]-2,3-dioxo-1-methylpyrrolidine-4-carboxamide

1-methylpyrrolidine-2,3-dione

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