2,4(1H,3H)-Pyrimidinedione, 3-(4-methylphenyl)-

Base Information

• Chemical Name: 2,4(1H,3H)-Pyrimidinedione, 3-(4-methylphenyl)-
• CAS No.: 4260-41-7
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.213
• Mol file: 4260-41-7.mol

Synonyms:

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 3-(4-methylphenyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 3-(4-methylphenyl)-

There total 3 articles about 2,4(1H,3H)-Pyrimidinedione, 3-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1R,2R,7S,8S)-5-p-Tolyl-3,5-diaza-tricyclo[6.2.1.02,7]undec-9-ene-4,6-dione (113094-25-0) → 3-(4-methylphenyl)-2,3-dihydropyrimidin-4(1H)-one (4260-41-7)

Guidance literature:

for 0.166667h; Heating;

DOI:10.1016/S0040-4020(01)81504-0

Reference yield:

p-tolylurea (622-51-5) + orthoformic acid triethyl ester (122-51-0) + Polymer: 4-phenylbutan-2-one cyclic malonic acid ester, bound to Merrifield resin → 3-(4-methylphenyl)-2,3-dihydropyrimidin-4(1H)-one (4260-41-7)

Guidance literature:

orthoformic acid triethyl ester; Polymer: 4-phenylbutan-2-one cyclic malonic acid ester, bound to Merrifield resin; for 6h; Heating;

p-tolylurea; for 12h; Heating;

at 220 - 240 ℃; for 0.333333h; Further stages.;

DOI:10.1021/jo020175m

Reference yield:

(1S,2S,3R,4R)-3-Amino-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid p-tolylamide (109853-40-9) → 3-(4-methylphenyl)-2,3-dihydropyrimidin-4(1H)-one (4260-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / benzene / 8 h / Heating

2: 80 percent / 0.17 h / Heating

In benzene;

DOI:10.1016/S0040-4020(01)81504-0

upstream raw materials:

(1R,2R,7S,8S)-5-p-Tolyl-3,5-diaza-tricyclo[6.2.1.0^2,7]undec-9-ene-4,6-dione

p-tolylurea

orthoformic acid triethyl ester

(1S,2S,3R,4R)-3-Amino-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid p-tolylamide

Refernces

• 1、 Bernath, Gabor,Stajer, Geza,Szabo, Angela E.,Szoeke-Molnar, Zsolt,Sohar, Pal,et al.. "STEREOCHEMICAL STUDIES 107; SATURATED HETEROCYCLES 111; PREPARATION OF URACILS VIA CYCLOREVERSION OF NORBORNENE-FUSED PYRIMIDINEDIONES". . p. 1921 - 1930. Retrieved 2007/10/02.