2-Amino-5-iodo-3-nitropyridine

Base Information

• Chemical Name: 2-Amino-5-iodo-3-nitropyridine
• CAS No.: 25391-57-5
• Molecular Formula: C5H4IN3O2
• Molecular Weight: 265.01
• Hs Code.: 2933399090
• European Community (EC) Number: 626-879-6
• DSSTox Substance ID: DTXSID10391991
• Wikidata: Q72440024
• Mol file: 25391-57-5.mol

Synonyms:2-Amino-5-iodo-3-nitropyridine;25391-57-5;5-iodo-3-nitropyridin-2-amine;2-Pyridinamine, 5-iodo-3-nitro-;2-AMINO-3-NITRO-5-IODOPYRIDINE;MFCD04038464;5-Iodo-3-nitro-2-aminopyridine;SCHEMBL1601280;DTXSID10391991;MDJUWRHSXKZSOJ-UHFFFAOYSA-N;AMY28685;AKOS005257300;PB23379;2-Amino-5-iodo-3-nitropyridine, 97%;DS-12470;SY041319;CS-0041316;FT-0638518;A817841;J-015977;5-iodo-3-nitro-pyridin-2-amine;5-Iodo-3-nitropyridin-2-amine

Chemical Property of 2-Amino-5-iodo-3-nitropyridine

Chemical Property:

• Vapor Pressure: 1.57E-05mmHg at 25°C
• Melting Point: 215-219 °C(lit.)
• Refractive Index: 1.742
• Boiling Point: 365.4 °C at 760 mmHg
• PKA: 0.41±0.49(Predicted)
• Flash Point: 174.8 °C
• PSA: 84.73000
• Density: 2.229 g/cm³
• LogP: 2.28100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 264.93482
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-iodo-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1[N+](=O)[O-])N)I
• Uses: 2-Amino-5-iodo-3-nitropyridine is used in the synthetic preparation of disubstituted pyridinyl azabicyclo heptanes as epibatidine analogs. These analogs are evaluated for its affinity for nicotinic acetylcholine receptors via in vitro and antinociceptive properties via in vivo in rats.

Technology Process of 2-Amino-5-iodo-3-nitropyridine

There total 2 articles about 2-Amino-5-iodo-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-3-nitropyridine (4214-75-9) → 5-Iodo-3-nitro-2-aminopyridine (25391-57-5)

Guidance literature:

2-amino-3-nitropyridine; With sulfuric acid; acetic acid; periodic acid; at 90 ℃; for 0.25h;

With iodine; for 1h; Further stages.;

DOI:10.1021/jm0202268

Reference yield: 79.0%

2-amino-3-nitropyridine (4214-75-9) + HIO4*2H2O → 5-Iodo-3-nitro-2-aminopyridine (25391-57-5)

Guidance literature:

With sulfuric acid; acetic acid; In water;

Reference yield: 97.0%

5-Iodo-3-nitro-2-aminopyridine (25391-57-5) → 5-iodopyridine-2,3-diamine (426463-01-6)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 100 ℃;

upstream raw materials:

2-amino-3-nitropyridine

Downstream raw materials:

5-iodopyridine-2,3-diamine

2-chloro-5-iodo-3-nitro-pyridine

5-amino-6-chloro-3-iodopyridine

2-fluoro-5-iodo-3-nitropyridine

Refernces

• 1、 -. "Synthetic method of 2-bromo-5-iodopyridin-3-amine". Paragraph 0006; 0009. . Retrieved 2017/11/29.
• 2、 -. "PROTEIN KINASE INHIBITORS". Page/Page column 37. . Retrieved 2013/04/25.