N-(4-methylphenyl)methanesulfonamide

Base Information

• Chemical Name: N-(4-methylphenyl)methanesulfonamide
• CAS No.: 4284-47-3
• Molecular Formula: C8H11NO2S
• Molecular Weight: 185.247
• Hs Code.: 2935009090
• European Community (EC) Number: 661-541-1
• Nikkaji Number: J1.711.916H
• Mol file: 4284-47-3.mol

Synonyms:N-(4-methylphenyl)methanesulfonamide;N-p-Tolylmethanesulfonamide;4284-47-3;N-methylphenylmethanesulfamide;SCHEMBL82733;JSSIRQJITXDDGR-UHFFFAOYSA-N;STL382118;AKOS002285544;SB76761;F3386-1747

Chemical Property of N-(4-methylphenyl)methanesulfonamide

Chemical Property:

• PSA: 54.55000
• LogP: 2.52030
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 185.05104977
• Heavy Atom Count: 12
• Complexity: 222

Purity/Quality:

95% ^*data from raw suppliers

N-(4-methylphenyl)methanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NS(=O)(=O)C

Technology Process of N-(4-methylphenyl)methanesulfonamide

There total 12 articles about N-(4-methylphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonamide (3144-09-0) + para-bromotoluene (106-38-7) → N-(4-methylphenyl)methanesulfonamide (4284-47-3)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tert-Amyl alcohol; at 80 ℃; Kinetics; Inert atmosphere;

DOI:10.1021/jo200443u

Reference yield: 97.0%

4-methylphenylboronic acid (5720-05-8) + Methanesulfonyl azide (624-90-8,1516-70-7) → N-(4-methylphenyl)methanesulfonamide (4284-47-3)

Guidance literature:

With copper(l) chloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ol403717

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + methanesulfonyl chloride (124-63-0) → N-(4-methylphenyl)methanesulfonamide (4284-47-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo010681w

upstream raw materials:

p-toluidine

methanesulfonyl chloride

C₂₇H₂₆NO₄PS₂

methanesulfonamide

Downstream raw materials:

N-(2-chloro-4-methylphenyl)methanesulfonamide

methanesulfonic acid-(2,3,5,6-tetrachloro-4-methyl-anilide)

N-(4-Methyl-2-pyrrolidin-1-ylmethyl-phenyl)-methanesulfonamide

N-(3,3-Diethoxy-propyl)-N-p-tolyl-methanesulfonamide

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