1-Cyclohexene-1-carboxaldehyde, 4-hydroxy-2,6,6-trimethyl-, (4R)-

Base Information

• Chemical Name: 1-Cyclohexene-1-carboxaldehyde, 4-hydroxy-2,6,6-trimethyl-, (4R)-
• CAS No.: 42926-75-0
• Molecular Formula: C10H16O2
• Molecular Weight: 168.23300
• Mol file: 42926-75-0.mol

Synonyms:3-hydroxy-β-cyclocitral;(-)-4-Hydroxy-2,6,6-trimethyl-cyclohex-1-encarbaldehyd;(-)-4-hydroxy-2,6,6-trimethyl-cyclohex-1-enecarbaldehyde;2,6,6-trimethyl-4-hydroxy-1-cyclohexene-1-carboxaldehyde;

Chemical Property of 1-Cyclohexene-1-carboxaldehyde, 4-hydroxy-2,6,6-trimethyl-, (4R)-

Chemical Property:

• PSA: 37.30000
• LogP: 1.68270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Cyclohexene-1-carboxaldehyde, 4-hydroxy-2,6,6-trimethyl-, (4R)-

There total 19 articles about 1-Cyclohexene-1-carboxaldehyde, 4-hydroxy-2,6,6-trimethyl-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3,4-epoxy-2,6,6-trimethylcyclohex-1-enecarbonitrile (535950-00-6) → 2,6,6-trimethyl-4-hydroxy-1-cyclohexene-1-carboxaldehyde (42926-75-0,76686-22-1,93219-56-8,35692-94-5)

Guidance literature:

3,4-epoxy-2,6,6-trimethylcyclohex-1-enecarbonitrile; With diisobutylaluminium hydride; In hexane; Petroleum ether; at -60 - 20 ℃; for 3h;

With silica gel; In water; toluene; at -20 - 0 ℃; for 1h;

DOI:10.1002/ejoc.200390130

Reference yield: 66.0%

C11H18O (1373498-18-0) → 2,6,6-trimethyl-4-hydroxy-1-cyclohexene-1-carboxaldehyde (42926-75-0,76686-22-1,93219-56-8,35692-94-5)

Guidance literature:

C₁₁H₁₈O; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; at 20 ℃; for 4h;

With sodium periodate; In water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1055/s-0031-1290353

Reference yield: 53.0%

(4R)-4-hydroxy-2,6,6-trimethyl-1-cyclohexene-1-methanol (76686-20-9) → (4R)-4-hydroxy-2,6,6-trimethyl-1-cyclohexene-1-carbaldehyde (42926-75-0)

Guidance literature:

With sodium acetate; pyridinium chlorochromate; In 1,4-dioxane; dichloromethane; for 4h; Ambient temperature;

DOI:10.1002/hlca.19800630615

upstream raw materials:

3,4-epoxy-2,6,6-trimethylcyclohex-1-enecarbonitrile

2,6,6-trimethylcyclohexa-1,3-dienecarbonitrile

2,6,6-trimethyl-2-cyclohexenecarbonitrile

3-hydroxy-2,6,6-trimethylcyclohex-1-enecarbonitrile

Downstream raw materials:

safranal

(3RS,all-E)-hydroxyretinal

C₂₀H₂₈O₂