2-Acridinecarboxylic acid, 9,10-dihydro-9-oxo-

Base Information

• Chemical Name: 2-Acridinecarboxylic acid, 9,10-dihydro-9-oxo-
• CAS No.: 42946-36-1
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Mol file: 42946-36-1.mol

Synonyms:9-oxo-9,10-dihydro-acridine-2-carboxylic acid;9-Oxo-9,10-dihydro-acridin-2-carbonsaeure;2-Acridinecarboxylic acid,9,10-dihydro-9-oxo;9-Oxo-9,10-dihydro-2-acridinecarboxylic acid;9-oxoacridan-3-carboxylic acid;9,10-dihydro-9-oxoacridine-2-carboxylic acid;acridone-2-carboxylic acid;

Chemical Property of 2-Acridinecarboxylic acid, 9,10-dihydro-9-oxo-

Chemical Property:

• Melting Point: 325 °C(Solv: ethanol (64-17-5))
• Boiling Point: 480.6±34.0 °C(Predicted)
• PSA: 70.16000
• Density: 1.397±0.06 g/cm3(Predicted)
• LogP: 2.37950

Purity/Quality:

9-Oxo-9,10-dihydroacridine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acridinecarboxylic acid, 9,10-dihydro-9-oxo-

There total 9 articles about 2-Acridinecarboxylic acid, 9,10-dihydro-9-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(4-carboxyphenyl)anthranilic acid (17332-57-9) → 9-oxo-9,10-dihydro-acridine-2-carboxylic acid (42946-36-1)

Guidance literature:

With PPA; at 120 ℃;

DOI:10.1021/jm400794z

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 9-oxo-9,10-dihydro-acridine-2-carboxylic acid (42946-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 43.1 percent / potassium carbonate; pyridine; Cu / CuI / H₂O / 4 h / Heating

2: POCl₃ / 1 h / Heating

3: aq.HCl / 2 h / Heating

With pyridine; hydrogenchloride; copper; potassium carbonate; trichlorophosphate; copper(l) iodide; In water; 1: Ulmann-Goldberg coupling;

DOI:10.1016/j.bmc.2006.04.044

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → 9-oxo-9,10-dihydro-acridine-2-carboxylic acid (42946-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 43.1 percent / potassium carbonate; pyridine; Cu / CuI / H₂O / 4 h / Heating

2: POCl₃ / 1 h / Heating

3: aq.HCl / 2 h / Heating

With pyridine; hydrogenchloride; copper; potassium carbonate; trichlorophosphate; copper(l) iodide; In water; 1: Ulmann-Goldberg coupling;

DOI:10.1016/j.bmc.2006.04.044

upstream raw materials:

N-(4-carboxyphenyl)anthranilic acid

2-<(3-carboxyphenyl)amino>benzoic acid

9-Chloro-acridine-2-carbonyl chloride

4-amino-benzoic acid

Downstream raw materials:

acridine-2-carboxylic acid