(3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine

Base Information

Chemical Name:(3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine
CAS No.:429673-86-9
Molecular Formula:C6H14N2O
Molecular Weight:130.18800
Hs Code.:
DSSTox Substance ID:DTXSID60565908
Wikidata:Q82451244
Mol file:429673-86-9.mol

Synonyms:(3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine;429673-86-9;DTXSID60565908;AKOS006355243

Suppliers and Price of (3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine

Chemical Property:

Boiling Point:182.8±40.0 °C(Predicted)
PKA:9.58±0.40(Predicted)
PSA：33.29000
Density:0.98±0.1 g/cm3(Predicted)
LogP:-0.08770
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:130.110613074
Heavy Atom Count:9
Complexity:87.1

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1CNCC1OC
Isomeric SMILES:CN[C@@H]1CNC[C@H]1OC

Technology Process of (3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine

There total 12 articles about (3R,4R)-4-methoxy-N-methylpyrrolidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945483-46-5
(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

: 252574-01-9,429673-86-9,771441-59-9,737726-89-5
(3S,4S)-3-methoxy-4-(N-methylammmonio)pyrrolidinium

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 48h; under 3800.26 Torr;
DOI:10.1039/b704932c DOI:10.1039/b604835h

Reference yield:

: 945483-50-1
(3R,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-α-methylbenzylamino]pyrrolidine

: 429673-86-9,771441-59-9,737726-89-5
(3R,4S)-3-methoxy-4-(N-methylammonio)pyrrolidinium

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 48h; under 3800.26 Torr;
DOI:10.1039/b704932c

Reference yield:

: 906750-09-2
methyl (3R,αS)-3-[N-methyl-N-(α-methylbenzyl)amino]-4-(N'-benzyl-N'-allylamino)butanoate

: 252574-01-9,429673-86-9,771441-59-9,737726-89-5
(3S,4S)-3-methoxy-4-(N-methylammmonio)pyrrolidinium

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,3-dimethyl barbituric acid / Pd(PPh₃)4 / CH₂Cl₂ / 12 h / 20 °C

2.1: 455 mg / SiO₂ / CH₂Cl₂

3.1: BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 2 h / -78 °C

3.2: 86 percent / (+)-(camphorsulfonyl)oxaziridine / tetrahydrofuran; hexane / 16 h / -78 - 20 °C

4.1: 95 percent / NaH / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 94 percent / LiAlH₄ / tetrahydrofuran / 12 h / Heating

6.1: H₂ / Pd(OH)2/C / methanol / 48 h / 3800.26 Torr

With 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; hydrogen; silica gel; sodium hydride; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/b704932c