Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)-

Base Information

Chemical Name:Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)-
CAS No.:430459-44-2
Molecular Formula:C13H8F2O5
Molecular Weight:282.2
Hs Code.:
DSSTox Substance ID:DTXSID90478890
Nikkaji Number:J1.726.432J
Mol file:430459-44-2.mol

Synonyms:bis(5-fluoro-2,4-dihydroxyphenyl)methanone;430459-44-2;Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)-;5,5'-difluoro-2,2',4,4'-tetrahydroxybenzophenone;SCHEMBL3429516;C13H8F2O5;DTXSID90478890;XPOHFOREFHRMND-UHFFFAOYSA-N;E87857;5,5'-difluoro-2, 2',4,4'-tetrahydroxybenzophenone

Suppliers and Price of Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:282.03397968
Heavy Atom Count:20
Complexity:335

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)O)O)C(=O)C2=CC(=C(C=C2O)O)F

Technology Process of Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)-

There total 15 articles about Methanone, bis(5-fluoro-2,4-dihydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 879288-16-1
bis(5-fluoro-2,4-dimethoxyphenyl)methanone

: 430459-44-2
5,5'-difluoro-2,2',4,4'-tetrahydroxybenzophenone

Guidance literature:: With boron tribromide; In dichloromethane; at 40 ℃;
DOI:10.1021/ol052655g

Reference yield: 10.0%

: 156217-21-9
bis(2,4,5-trifluorophenyl)methanone

: 1350807-58-7
bis(2,5-difluoro-4-hydroxyphenyl)methanone

: 430459-44-2
5,5'-difluoro-2,2',4,4'-tetrahydroxybenzophenone

Guidance literature:: With 18-crown-6 ether; potassium hydroxide; In water; at 100 ℃; for 12h;
DOI:10.1055/s-0033-1338535

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 430459-44-2
5,5'-difluoro-2,2',4,4'-tetrahydroxybenzophenone

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / methanol

2: 91 percent / H₂ / Pd/C / ethanol

3: 68 percent / HCl; NaNO₂; NaI / H₂O / 16 h / 0 - 22 °C

4: 96 percent / acetonitrile / 0.01 h / microwave irradiation

5: 72 percent / BBr₃ / CH₂Cl₂ / 40 °C

With hydrogenchloride; hydrogen; boron tribromide; sodium iodide; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetonitrile; 3: Sandmeyer reaction;
DOI:10.1021/ol052655g