[R,(-)]-Chlorophenylacetic acid

Base Information

• Chemical Name: [R,(-)]-Chlorophenylacetic acid
• CAS No.: 43195-94-4
• Molecular Formula: C8H7ClO2
• Molecular Weight: 170.595
• Mol file: 43195-94-4.mol

Synonyms:(R)-2-chlorophenylacetic acid;(R)-Chlor-phenyl-essigsaeure;Benzeneacetic acid, α-chloro-, (R)-;(R)-chloro-phenyl-acetic acid;

Chemical Property of [R,(-)]-Chlorophenylacetic acid

Chemical Property:

• Boiling Point: 282.0±20.0 °C(Predicted)
• PKA: 2.40±0.10(Predicted)
• PSA: 37.30000
• Density: 1.322±0.06 g/cm3(Predicted)
• LogP: 2.05110

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [R,(-)]-Chlorophenylacetic acid

There total 18 articles about [R,(-)]-Chlorophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-3-(2-chloro-2-phenylacetyl)oxazolidin-2-one (1355255-19-4) → (S)-2-Chloro-2-phenylacetic acid (29125-24-4) + (R)-2-chloro-2-phenylacetic acid (43195-94-4)

Guidance literature:

With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; enantioselective reaction;

DOI:10.1002/ejoc.201100453

Reference yield: 51.6%

(R)-Mandelic Acid (611-71-2) → (R)-2-chloro-2-phenylacetic acid (43195-94-4)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃;

Reference yield:

2-chloro-2-phenylacetonitrile (22259-83-2) → (S)-2-Chloro-2-phenylacetic acid (29125-24-4) + (S)-chloro-phenyl-acetic acid amide (360557-73-9) + (R)-chloro-phenyl-acetic acid amide (7462-76-2,56598-64-2) + (R)-2-chloro-2-phenylacetic acid (43195-94-4)

Guidance literature:

With recombinant nitrilase from Pseudomonas fluorescens EBC 191; In methanol; phosphate buffer; at 25 ℃; pH=6; Title compound not separated from byproducts;

DOI:10.1002/adsc.200600269

upstream raw materials:

(2-nitroethenyl)benzene

Chloro-phenyl-acetic acid

(RS)-mandelonitrile

phenylglycin

Downstream raw materials:

MANDELIC ACID

(R)-chloro-phenyl-acetic acid-chloride

benzaldehyde phenylhydrazone

phenylacetic acid