S-2-Chloro-2-phenylacetic acid

Base Information

• Chemical Name: S-2-Chloro-2-phenylacetic acid
• CAS No.: 29125-24-4
• Molecular Formula: C8H7 Cl O2
• Molecular Weight: 170.595
• Mol file: 29125-24-4.mol

Synonyms:Aceticacid, chlorophenyl-, L-(+)- (8CI); Benzeneacetic acid, a-chloro-, (S)-; Acetic acid,2-chloro-2-phenyl-L-(+)-

Chemical Property of S-2-Chloro-2-phenylacetic acid

Chemical Property:

• Melting Point: 60-61 °C(Solv: ethanol (64-17-5))
• Boiling Point: 125-126 °C(Press: 3 Torr)
• PKA: 2.40±0.10(Predicted)
• PSA: 37.30000
• Density: 0.8837 g/cm3
• LogP: 2.05110

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Chloro-2-phenylaceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-2-Chloro-2-phenylacetic acid

There total 13 articles about S-2-Chloro-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-3-(2-chloro-2-phenylacetyl)oxazolidin-2-one (1355255-19-4) → (S)-2-Chloro-2-phenylacetic acid (29125-24-4) + (R)-2-chloro-2-phenylacetic acid (43195-94-4)

Guidance literature:

With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; enantioselective reaction;

DOI:10.1002/ejoc.201100453

Reference yield:

2-chloro-2-phenylacetonitrile (22259-83-2) → (S)-2-Chloro-2-phenylacetic acid (29125-24-4) + (S)-chloro-phenyl-acetic acid amide (360557-73-9) + (R)-chloro-phenyl-acetic acid amide (7462-76-2,56598-64-2) + (R)-2-chloro-2-phenylacetic acid (43195-94-4)

Guidance literature:

With recombinant nitrilase from Pseudomonas fluorescens EBC 191; In methanol; phosphate buffer; at 25 ℃; pH=6; Title compound not separated from byproducts;

DOI:10.1002/adsc.200600269

Reference yield:

1,1-bis(trimethylsilyloxy)-2-chloro-2-phenylethene (181026-78-8) → (S)-2-Chloro-2-phenylacetic acid (29125-24-4) + (R)-2-chloro-2-phenylacetic acid (43195-94-4)

Guidance literature:

With (R)-LBA⁽¹⁾; In dichloromethane; at -78 ℃; for 0.166667h; Product distribution; other ketene bis(trimethylsilyl)acetals;

upstream raw materials:

α-chlorophenylacetyl chloride

Chloro-phenyl-acetic acid

ethyl 2-chloro-2-phenylacetate

1,1-bis(trimethylsilyloxy)-2-chloro-2-phenylethene

Downstream raw materials:

(R)-mandelic acid ethyl ester

(S)-2-chloro-2-phenylacetic acid ethyl ester

C₈H₆Cl₂O

phenylglycin