3-Chloro-5-(trifluoromethoxy)benzaldehyde

Base Information

• Chemical Name: 3-Chloro-5-(trifluoromethoxy)benzaldehyde
• CAS No.: 433926-48-8
• Molecular Formula: C8H4ClF3O2
• Molecular Weight: 224.567
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID10590669
• Wikidata: Q82484306
• Mol file: 433926-48-8.mol

Synonyms:3-Chloro-5-(trifluoromethoxy)benzaldehyde;433926-48-8;3-Chloro-5-trifluoromethoxybenzaldehyde;Benzaldehyde, 3-chloro-5-(trifluoromethoxy)-;SCHEMBL3162925;DTXSID10590669;CL9437;MFCD06660305;AKOS015956818;AS-46347;DB-094218;CS-0021646

Chemical Property of 3-Chloro-5-(trifluoromethoxy)benzaldehyde

Chemical Property:

• Refractive Index: 1.4765
• Boiling Point: 220.6±35.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.463±0.06 g/cm3(Predicted)
• LogP: 3.05110
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• Water Solubility.: Soluble in water (3.3 g/L (20°C)).
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 223.9851915
• Heavy Atom Count: 14
• Complexity: 207

Purity/Quality:

98% ^*data from raw suppliers

3-Chloro-5-(trifluoromethoxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=C(C=C1OC(F)(F)F)Cl)C=O
• Uses: 3-Chloro-5-(trifluoromethoxy)benzaldehyde is used as pharmaceutical intermediates

Technology Process of 3-Chloro-5-(trifluoromethoxy)benzaldehyde

There total 1 articles about 3-Chloro-5-(trifluoromethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3-chloro-5-trifluoromethoxy-phenyl)-methanol (433926-47-7) → 3-chloro-5-(trifluoromethoxy)benzaldehyde (433926-48-8)

Guidance literature:

(3-chloro-5-trifluoromethoxy-phenyl)-methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1.16667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 19.6667h;

Reference yield: 96.0%

3-chloro-5-(trifluoromethoxy)benzaldehyde (433926-48-8) + trimethylsilyl cyanide (7677-24-9) → Ph(3-Cl)(5-OCF3)-(R,S)CH(OTMS)CN (433938-47-7)

Guidance literature:

3-chloro-5-(trifluoromethoxy)benzaldehyde; trimethylsilyl cyanide; zinc(II) iodide; In dichloromethane; at 0 - 20 ℃; for 21.5h;

With water; In dichloromethane;

Reference yield: 33.0%

3-chloro-5-(trifluoromethoxy)benzaldehyde (433926-48-8) + p-toluenesulfonyl chloride (98-59-9) → 3-chloro-5-(trifluoromethoxy)benzyl 4-methylbenzenesulfonate

Guidance literature:

3-chloro-5-(trifluoromethoxy)benzaldehyde; With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Inert atmosphere;

p-toluenesulfonyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2.5h;

upstream raw materials:

(3-chloro-5-trifluoromethoxy-phenyl)-methanol

Downstream raw materials:

Ph(3-Cl)(5-OCF₃)-(R,S)CH(OTMS)CN

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 433926-48-8 3-CHLORO-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send