2,4-DiaMino-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid

Base Information

• Chemical Name: 2,4-DiaMino-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid
• CAS No.: 6974-25-0
• Molecular Formula: C₉H₁₂N₄O₂
• Molecular Weight: 208.22
• Hs Code.: 2933990090
• Mol file: 6974-25-0.mol

Synonyms:NSC 23115

Chemical Property of 2,4-DiaMino-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid

Chemical Property:

• Vapor Pressure: 8.88E-15mmHg at 25°C
• Boiling Point: 590.3°Cat760mmHg
• Flash Point: 310.8°C
• PSA: 115.12000
• Density: 1.492g/cm³
• LogP: 0.99290

Purity/Quality:

2,4-Diamino-5,6,7,8-tetrahydro-6-quinazolinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Diamino-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid, is a substituted 6-substituted 5,6,7,8-tetrahydroquinazolines, used for the synthesis of potential anticancer agents.

Technology Process of 2,4-DiaMino-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid

There total 3 articles about 2,4-DiaMino-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid (5458-56-0) → 2,4-diamino-5,6,7,8-tetrahydro-quinazoline-6-carboxylic acid (6974-25-0)

Guidance literature:

With ethanol; ammonia; at 150 ℃;

DOI:10.1021/jo01093a004

Reference yield:

4-oxo-cyclohexane-1,3-dicarboxylic acid dimethyl ester (103505-09-5) → 2,4-diamino-5,6,7,8-tetrahydro-quinazoline-6-carboxylic acid (6974-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol. sodium methylate / Beim anschliessenden Erhitzen mit wss. NaOH

2: POCl₃

3: ethanol; NH₃ / 150 °C

With ethanol; ammonia; sodium methylate; trichlorophosphate;

DOI:10.1021/jo01093a004

Reference yield:

2,4-dioxo-1,2,3,4,5,6,7,8-octahydro-quinazoline-6-carboxylic acid (5439-88-3) → 2,4-diamino-5,6,7,8-tetrahydro-quinazoline-6-carboxylic acid (6974-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: ethanol; NH₃ / 150 °C

With ethanol; ammonia; trichlorophosphate;

DOI:10.1021/jo01093a004

upstream raw materials:

2,4-dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid

4-oxo-cyclohexane-1,3-dicarboxylic acid dimethyl ester

2,4-dioxo-1,2,3,4,5,6,7,8-octahydro-quinazoline-6-carboxylic acid

Downstream raw materials:

toluene-4-sulfonic acid-(2,4-diamino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl ester)