Tert-butyl 4-{2-[4-(mesyloxy)piperidin-1-YL]-2-oxoethyl}piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-{2-[4-(mesyloxy)piperidin-1-YL]-2-oxoethyl}piperidine-1-carboxylate
CAS No.:440634-25-3
Molecular Formula:C18H32N2O6S
Molecular Weight:404.52100
Hs Code.:
European Community (EC) Number:610-165-6
DSSTox Substance ID:DTXSID20470569
Nikkaji Number:J1.876.510A
Wikidata:Q82298702
Mol file:440634-25-3.mol

Synonyms:440634-25-3;tert-butyl 4-(2-(4-((methylsulfonyl)oxy)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxylate;TERT-BUTYL 4-{2-[4-(MESYLOXY)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXYLATE;tert-butyl 4-[2-(4-methylsulfonyloxypiperidin-1-yl)-2-oxoethyl]piperidine-1-carboxylate;1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-mesyloxypiperidine;SCHEMBL4650039;DTXSID20470569;HCPHGCCJTBULLI-UHFFFAOYSA-N;AKOS037647462;AS-73754;CS-0062102;W17885;tert-butyl4-[2-(4-methylsulfonyloxypiperidin-1-yl)-2-oxoethyl]piperidine-1-carboxylate;TERT-BUTYL 4-{2-[4-(METHANESULFONYLOXY)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXYLATE

Suppliers and Price of Tert-butyl 4-{2-[4-(mesyloxy)piperidin-1-YL]-2-oxoethyl}piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
tert-butyl4-[2-(4-methylsulfonyloxypiperidin-1-yl)-2-oxoethyl]piperidine-1-carboxylate
5g
$ 646.40

Total 3 raw suppliers

Chemical Property of Tert-butyl 4-{2-[4-(mesyloxy)piperidin-1-YL]-2-oxoethyl}piperidine-1-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:577.854oC at 760 mmHg
PKA:-1.51±0.40(Predicted)
Flash Point:303.275oC
PSA：101.60000
Density:1.237g/cm3
LogP:2.94740
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:404.19810792
Heavy Atom Count:27
Complexity:621

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl4-[2-(4-methylsulfonyloxypiperidin-1-yl)-2-oxoethyl]piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)OS(=O)(=O)C

Technology Process of Tert-butyl 4-{2-[4-(mesyloxy)piperidin-1-YL]-2-oxoethyl}piperidine-1-carboxylate

There total 4 articles about Tert-butyl 4-{2-[4-(mesyloxy)piperidin-1-YL]-2-oxoethyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-hydroxypiperidine

: 124-63-0
methanesulfonyl chloride

: 440634-25-3
1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-mesyloxypiperidine

Guidance literature:: With triethylamine; In toluene; at 0 - 5 ℃; for 2h;

Reference yield: 79.8%

: 1-(1-benzyl-4-piperidylacetyl)-4-mesyloxypiperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 440634-25-3
1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-mesyloxypiperidine

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In water; isopropyl alcohol; at 50 ℃; for 2h; under 3750.38 Torr;

Reference yield: 42.5%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 24424-99-5
di-tert-butyl dicarbonate

: 40110-55-2
ethyl 2-(1-benzylpiperidine-4-ylidene)acetate

: 124-63-0
methanesulfonyl chloride

: 440634-25-3
1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-mesyloxypiperidine

Guidance literature:: 4-HYDROXYPIPERIDINE; ethyl 2-(1-benzylpiperidine-4-ylidene)acetate; With sodium methylate; In methanol; toluene; at 108 - 112 ℃; for 3h;

methanesulfonyl chloride; With triethylamine; In toluene; at 0 - 10 ℃; for 1h;

di-tert-butyl dicarbonate; With 5%-palladium/activated carbon; hydrogen; In isopropyl alcohol; at 50 ℃; for 10h; under 3750.38 Torr;