Technology Process of 1-Pyrrolidinecarboxylic acid,
2-(methoxymethyl)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester,
(2S,5S)-
There total 1 articles about 1-Pyrrolidinecarboxylic acid,
2-(methoxymethyl)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester,
(2S,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 15 h
2: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 60 °C
3: Rh/Al2O3; hydrogen / acetic acid; ethanol / 2.5 h / 20 °C / 8?atm
4: sodium methylate / methanol / Reflux
5: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 20 °C
6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
di-isopropyl azodicarboxylate; palladium 10% on activated carbon; Rh/Al2O3; hydrogen; sodium methylate; triphenylphosphine; trifluoroacetic acid; diazomethyl-trimethyl-silane;
In
methanol; ethanol; hexane; dichloromethane; acetic acid; benzene;
2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003
- Guidance literature:
-
Multi-step reaction with 7 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 15 h
2: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 60 °C
3: Rh/Al2O3; hydrogen / acetic acid; ethanol / 2.5 h / 20 °C / 8?atm
4: sodium methylate / methanol / Reflux
5: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 20 °C
6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C
With
di-isopropyl azodicarboxylate; palladium 10% on activated carbon; Rh/Al2O3; hydrogen; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; diazomethyl-trimethyl-silane;
In
methanol; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; benzene;
2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003
