Glycine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(phenylmeth oxy)phenyl]propyl]-, methyl ester

Base Information

Chemical Name:Glycine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(phenylmeth oxy)phenyl]propyl]-, methyl ester
CAS No.:442129-00-2
Molecular Formula:C25H34N2O5
Molecular Weight:442.555
Hs Code.:

Synonyms:

Suppliers and Price of Glycine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(phenylmeth oxy)phenyl]propyl]-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Glycine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(phenylmeth oxy)phenyl]propyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Glycine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(phenylmeth oxy)phenyl]propyl]-, methyl ester

There total 6 articles about Glycine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(phenylmeth oxy)phenyl]propyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 616-34-2
methoxycarbonylmethylamine

: 442128-96-3
(1S)-3-(4-benzyloxyphenyl)-2-[(N)-tert-butoxycarbonyl]methylaminopropanal

: 442129-00-2
methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylmethylamino)propyl]aminoacetate

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1016/S0040-4039(02)00296-4

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 442129-00-2
methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylmethylamino)propyl]aminoacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / K₂CO₃ / dioxane; H₂O / 2 h / 0 °C

2: 88 percent / K₂CO₃ / acetone / 12 h / 20 °C

3: 92 percent / lithium aluminum hydride / tetrahydrofuran / 4 h / Heating

4: 92 percent / K₂CO₃ / tetrahydrofuran; H₂O / 12 h / 20 °C

5: 86 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

6: 87 percent / NaBH₃CN / methanol / 4 h / 0 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone;
DOI:10.3987/com-03-s(p)14

Reference yield:

: 215596-38-6
(S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester

: 442129-00-2
methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylmethylamino)propyl]aminoacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / K₂CO₃ / acetone / 12 h / 20 °C

2: 92 percent / lithium aluminum hydride / tetrahydrofuran / 4 h / Heating

3: 92 percent / K₂CO₃ / tetrahydrofuran; H₂O / 12 h / 20 °C

4: 86 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

5: 87 percent / NaBH₃CN / methanol / 4 h / 0 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.3987/com-03-s(p)14