442128-96-3

Upstream product

• 442128-91-8 1,1-dimethylethyl N-[(1S)-2-hydroxy-1-{[4-(phenylmethoxy)phenyl]methyl}ethyl]-N-methylcarbamate 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 100-39-0 benzyl bromide 
• 27513-44-6 N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester 
• 251555-87-0 C₂₃H₂₉NO₅ 
• 442128-78-1 methyl (2S)-3-(4-benzyloxyphenyl)-2-ethoxycarbonylaminopropionate 
• 442128-85-0 (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine 
• 215596-38-6 (S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester 

Downstream Products

• 442129-00-2 methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylmethylamino)propyl]aminoacetate 
• 442129-12-6 (6S)-6-(4-hydroxybenzyl)-1-methylpiperazin-2-one 
• 442129-08-0 (6S)-6-(4-benzyloxybenzyl)-1-methylpiperazin-2-one 
• 442129-04-6 methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-methylaminopropyl]aminoacetate 
• 1370332-25-4 C₂₀H₂₃NO₃ 
• 1370332-26-5 C₂₀H₂₃NO₃ 
• 1370332-27-6 C₂₀H₂₃NO₃ 
• 1370332-11-8 C₂₀H₂₃NO₃ 
• 1370332-12-9 C₂₇H₃₇NO₆ 

Relevant academic research and scientific papers

Total synthesis of a pyrrolidin-2-one with the structure proposed for the alkaloid rigidiusculamide A

The total synthesis of the pyrrolidinone alkaloid rigidiusculamide A is reported starting from L-tyrosine, using amidation, ring-closing metathesis, and dihydroxylation as the key reactions. Copyright

A formal synthesis of a muscarinic M1 receptor antagonist, (-)-TAN1251A

An aromatic oxidation reaction of a secondary amine, prepared from L-tyrosine and glycine, with hypervalent iodine reagent gave a spirocyclic product, which was further converted into the key intermediate for the synthesis of (-)-TAN1251A.

Facile synthesis of enantiopure (-)-TAN1251A

Formal total synthesis of enantiopure (-)-TAN1251A, a muscarinic M1 receptor antagonist, was achieved via a spirocyclic carbon-nitrogen bond formation by the use of aromatic oxidation with bis(acetoxy)iodobenzene as a key step.