Technology Process of 1H-Benz[g]indole-2-carboxylic acid, 1-(cyclohexylmethyl)-4-methoxy-,
ethyl ester
There total 6 articles about 1H-Benz[g]indole-2-carboxylic acid, 1-(cyclohexylmethyl)-4-methoxy-,
ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-carboethoxy-4-methoxybenz[g]indole;
With
sodium hydride;
In
N,N-dimethyl-formamide;
for 0.5h;
Cyclohexylmethyl bromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 168h;
DOI:10.1021/jm0401309
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 91 percent / Cs2CO3 / 32 h / Heating
2.1: 93 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
3.1: 92 percent / 4-methylmorpholine N-oxide; tetrapropylammonium perruthenate / CH2Cl2
4.1: 75 percent / NaOEt / diethyl ether / 22 h / 10 - 20 °C
5.1: 82 percent / toluene / 3 h / Heating
6.1: NaH / dimethylformamide / 0.5 h
6.2: 90 percent / dimethylformamide / 168 h / 20 °C
With
lithium aluminium tetrahydride; tetrapropylammonium perruthennate; sodium ethanolate; sodium hydride; caesium carbonate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0401309
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 75 percent / NaOEt / diethyl ether / 22 h / 10 - 20 °C
2.1: 82 percent / toluene / 3 h / Heating
3.1: NaH / dimethylformamide / 0.5 h
3.2: 90 percent / dimethylformamide / 168 h / 20 °C
With
sodium ethanolate; sodium hydride;
In
diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0401309
