Technology Process of Acetamide,
N-[(1S)-1-[4-[(4-chlorophenyl)thio]phenyl]ethyl]-2,2,2-trifluoro-
There total 4 articles about Acetamide,
N-[(1S)-1-[4-[(4-chlorophenyl)thio]phenyl]ethyl]-2,2,2-trifluoro- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide;
With
methyllithium;
In
tetrahydrofuran; diethyl ether;
at -75 - -60 ℃;
for 0.25h;
4,4'-dichlorodiphenyl disulfide;
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
at -65 ℃;
for 4.66667h;
- Guidance literature:
-
methyllithium; N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide;
In
tetrahydrofuran; diethyl ether;
at -75 - -60 ℃;
for 0.25h;
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
at -65 ℃;
for 0.666667h;
4,4'-dichlorodiphenyl disulfide;
In
tetrahydrofuran; diethyl ether; hexane;
for 3h;
DOI:10.1016/j.bmcl.2005.07.023
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: CH2Cl2 / 3 h / 20 °C
2.1: 46 g / dibromodimethyl hydantoin; methanesulfonic acid / CH2Cl2 / 20 °C
3.1: tetrahydrofuran; diethyl ether / 0.25 h / -75 - -60 °C
3.2: n-BuLi / tetrahydrofuran; hexane; diethyl ether / 0.67 h / -65 °C
3.3: tetrahydrofuran; hexane; diethyl ether / 3 h
With
methanesulfonic acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2005.07.023
