H-PRO-OET HCL

Base Information

• Chemical Name: H-PRO-OET HCL
• CAS No.: 33305-75-8
• Molecular Formula: C7H13 N O2 . Cl H
• Molecular Weight: 179.647
• Hs Code.: 2933990090
• Mol file: 33305-75-8.mol

Synonyms:L-Proline,ethyl ester, hydrochloride (9CI); Proline, ethyl ester, hydrochloride, L-(8CI); (S)-Proline ethyl ester hydrochloride; (S)-Pyrrolidine-2-carboxylic acidethyl ester hydrochloride; Ethyl L-prolinate hydrochloride; Proline ethyl esterhydrochloride

Chemical Property of H-PRO-OET HCL

Chemical Property:

• Vapor Pressure: 0.519mmHg at 25°C
• Boiling Point: 191.3°Cat760mmHg
• Flash Point: 69.5°C
• PSA: 38.33000
• Density: g/cm³
• LogP: 1.43230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

L-Proline ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PRO-OET HCL

There total 4 articles about H-PRO-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → L-proline ethyl ester monohydrochloride (33305-75-8,131477-20-8)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1016/0040-4020(95)00910-Z

Reference yield: 99.2%

→ L-proline ethyl ester monohydrochloride (33305-75-8,131477-20-8)

Guidance literature:

With pyridine; hydrogenchloride; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

With hydrogenchloride; In 1,2-dichloro-ethane; at 84 ℃; for 3h; Reflux;

Reference yield: 99.0%

ethanol (64-17-5) + L-threonine (72-19-5,134357-96-3,7013-32-3,82822-12-6) → L-proline ethyl ester monohydrochloride (33305-75-8,131477-20-8)

Guidance literature:

With thionyl chloride; at 80 ℃; for 16h;

upstream raw materials:

ethanol

L-proline

L-threonine

(2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Downstream raw materials:

N-benzoyl S-proline ethyl ester

N-carbobenzoxy-γ-aminobutyrylproline ethyl ester

N-stearoyl-L-Ser-L-Pro-OEt

(2S,2'S)-diethyl 1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

Refernces

• 1、 Yildirim, Muhammet,Suleiman, Garba. "A practical access to new pyrrolizine carboxylates via KHMDS-catalyzed carbocyclizations". supporting information. p. 463 - 481. Retrieved 2019/01/25.
• 2、 Moshikur, Rahman Md.,Chowdhury, Md. Raihan,Wakabayashi, Rie,Tahara, Yoshiro,Moniruzzaman, Muhammad,Goto, Masahiro. "Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids". . p. 31 - 38. Retrieved 2018/05/28.