Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

Base Information

Chemical Name:Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester
CAS No.:452979-25-8
Molecular Formula:C35H36F3N4O8PS
Molecular Weight:760.728
Hs Code.:

Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-,
(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]
-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth
yl)propyl ester

Synonyms:

Suppliers and Price of Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

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Technology Process of Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

There total 2 articles about Acetic acid, [[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 452978-15-3
(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl 2-hydroxyacetate

: 126429-21-8
diallyl diisopropylphosphoramidite

: 452979-25-8
diallyl 2-[(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propoxy]-2-oxoethyl phosphate

Guidance literature:: (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl 2-hydroxyacetate; diallyl diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; at 0 ℃; for 0.333333h;

With methanol; In dichloromethane; for 0.0833333h;

With tert.-butylhydroperoxide; sodium hydrogencarbonate; sodium thiosulfate; more than 3 stages;

Reference yield:

: C₃₅H₃₆F₃N₄O₇PS

: 452979-25-8
diallyl 2-[(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propoxy]-2-oxoethyl phosphate

Guidance literature:: With tert.-butylhydroperoxide; In dichloromethane;
DOI:10.1016/j.bmcl.2009.04.135

Reference yield:

: 452979-25-8
diallyl 2-[(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propoxy]-2-oxoethyl phosphate

: C₂₉H₂₈F₃N₄O₈PS

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride; In dichloromethane;
DOI:10.1016/j.bmcl.2009.04.135