3H-TRIAZOLO[4,5-B]PYRIDINE, 6-BROMO-

Base Information

• Chemical Name: 3H-TRIAZOLO[4,5-B]PYRIDINE, 6-BROMO-
• CAS No.: 92276-38-5
• Molecular Formula: C5H3 Br N4
• Molecular Weight: 199.01
• Hs Code.: 2933990090
• Mol file: 92276-38-5.mol

Synonyms:3H-v-Triazolo[4,5-b]pyridine,6-bromo- (7CI); v-Triazolo[4,5-b]pyridine, 6-bromo- (6CI); NSC 259161

Chemical Property of 3H-TRIAZOLO[4,5-B]PYRIDINE, 6-BROMO-

Chemical Property:

• Vapor Pressure: 0.000116mmHg at 25°C
• Melting Point: 209 °C
• Boiling Point: 272.9°Cat760mmHg
• PKA: 1.72±0.20(Predicted)
• Flash Point: 118.9°C
• PSA: 54.46000
• Density: 2.28g/cm³
• LogP: 1.11540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

6-Bromo-3H-[1,2,3]triazolo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-TRIAZOLO[4,5-B]PYRIDINE, 6-BROMO-

There total 3 articles about 3H-TRIAZOLO[4,5-B]PYRIDINE, 6-BROMO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-bromo-pyridine-2,3-diamine (38875-53-5) → 6-bromo-1H-[1,2,3]triazolo[4,5-b]pyridine (92276-38-5)

Guidance literature:

With acetic acid; sodium nitrite; for 1h; Sonication;

DOI:10.1021/acs.jmedchem.1c00323

Reference yield:

5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 6-bromo-1H-[1,2,3]triazolo[4,5-b]pyridine (92276-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride / water; ethanol / 1 h / Inert atmosphere; Reflux

2.1: sulfuric acid / water / 0 °C / Heating

2.2: 20 °C

With sulfuric acid; tin(ll) chloride; In ethanol; water;

DOI:10.1016/j.bioorg.2020.104502

Reference yield:

→ 6-bromo-1H-[1,2,3]triazolo[4,5-b]pyridine (92276-38-5)

Guidance literature:

/BRN= 127069/;

upstream raw materials:

5-bromo-pyridine-2,3-diamine

5-bromo-3-nitro-pyridin-2-ylamine

Downstream raw materials:

6-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine

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