6945-68-2

Basic information

• Product Name: 2-Amino-5-bromo-3-nitropyridine
• Synonyms: 5-BROMO-3-NITROPYRIDIN-2-AMINE;5-BROMO-3-NITRO-PYRIDIN-2-YLAMINE;2-AMINO-5-BROMO-3-NITROPYRIDINE;TIMTEC-BB SBB006560;2-Amino-3-nitro-5-bromopyridine;5-Bromo-3-Nitro-2-Pyridinamine;2-Pyridinamine, 5-bromo-3-nitro-;2-Amino-5-bromo-3-nitropyridine,98%
• CAS NO: 6945-68-2
• Molecular Formula: C₅H₄BrN₃O₂
• Molecular Weight: 218.01
• EINECS: -0
• Product Categories: compounds of pyridine;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridines;Bromopyridines;Halopyridines;Amines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Amino-pyridine series;Halogenated Heterocycles
• Mol File: 6945-68-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 205-208 °C(lit.)
• Boiling Point: 302.9 °C at 760 mmHg
• Flash Point: 137 °C
• Appearance: yellow-brown crystalline powder
• Density: 1.9128 (rough estimate)
• Vapor Pressure: 0.000964mmHg at 25°C
• Refractive Index: 1.6200 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.15±0.49(Predicted)
• BRN: 383851
• CAS DataBase Reference: 2-Amino-5-bromo-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-bromo-3-nitropyridine(6945-68-2)
• EPA Substance Registry System: 2-Amino-5-bromo-3-nitropyridine(6945-68-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36/37/39-22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6945-68-2(Hazardous Substances Data)

Usage

Chemical Properties

yellow-brown crystalline powder

Uses

2-Amino-5-bromo-3-nitropyridine may be used in the preparation of azaquinoxalinedione.

General Description

2-Amino-5-bromo-3-nitropyridine is formed as intermediate in the synthesis of 2,3-diaminopyridine.

InChI:InChI=1/C5H4BrN3O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H,(H2,7,8)/p+1

Upstream product

• 504-29-0 2-aminopyridine 
• 1072-98-6 5-chloro-2-pyridylamine 
• 7664-93-9 sulfuric acid 
• 33245-29-3 5-bromo-2-nitraminopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 7697-37-2 nitric acid 
• 170158-61-9 2-(N-bromo-N-nitro)aminopyridine 
• 412035-35-9 5-bromo-3-nitro-pyridine-2-carboxylic acid amide 
• 4214-75-9 2-amino-3-nitropyridine 

Downstream Products

• 640271-51-8 5-(4-Fluorophenyl)-3-nitropyridin-2-amine 
• 1167437-34-4 5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine 
• 1167437-40-2 5-[3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-3-nitropyridin-2-amine 
• 1452815-79-0 1-deazapurine N,N'-diphenylurea 
• 1452815-80-3 1-deazapurine 1-(2-cyanophenyl)-3-phenylurea 
• 1452815-81-4 1-deazapurine 1-(4-bromophenyl)-3-phenylurea 
• 1452815-83-6 1-deazapurine 1,2-diiodotetrafluorobenzene 
• 1452815-84-7 1-deazapurine 1,4-diiodotetrafluorobenzene 
• 273-21-2 3H-imidazo[4,5-b]pyridine 
• 38875-53-5 5-bromo-pyridine-2,3-diamine 
• 92276-38-5 6-bromo-1H-[1,2,3]triazolo[4,5-b]pyridine 
• 773884-58-5 3H-imidazo[4,5-b]pyridine-6-carbonitrile 
• 1003711-13-4 6-amino-5-nitronicotinonitrile 
• 152684-30-5 5-bromo-2-methoxy-3-nitropyridine 

Relevant articles and documents

Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors

Phosphoinositide 3-kinases (PI3Ks) are regarded as promising targets for treatment of various cancers due to their roles in regulating cell proliferation, differentiation, migration, and survival. Here we report our efforts to develop potent and orally bioavailable PI3K inhibitors for the treatment of cancers. The alkylsulfonamide-containing quinazoline derivatives A1–A18 significantly inhibited PI3Kα, and cell proliferation among HCT-116, MCF-7 and SU-DHL-6 cell lines. The optimal compound A1 displayed potent inhibitory activity against PI3Kα (IC50 = 4.5 nM), PI3Kβ (IC50 = 4.5 nM), PI3Kγ (IC50 = 4.5 nM), PI3Kδ (IC50 = 4.5 nM) and significantly inhibited the growth of HCT-116, MCF-7 and SU-DHL-6 cell lines with IC50 values of 0.82 μM, 0.99 μM and 0.19 μM, respectively. Western blot analysis demonstrated A1 significantly suppressed the phosphorylation of AKTS473 in a dose-dependent manner. Furthermore, A1 could markedly inhibit cancer growth at the dose of 25 mg/kg in nude mouse HCT-116 xenograft model in vivo without causing significant weight loss or toxicity.

New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons

A streamlined synthetic methodology towards novel tetracyclic 1,4-oxazepines from readily available precursors is described. The compounds, designed as more soluble version of the earlier described, poorly soluble dibenzo[b,f][1,4]oxazepines, were obtained in high yields and as a single regioisomer as a result of three tandem chemical events - nucleophilic aromatic substitution, Smiles rearrangement and denitrocyclization.

Synthesis and testing of new end-functionalized oligomers for molecular electronics

Several new classes of oligomers have been synthesized with functionalities designed to aid in the understanding of molecular device behavior, specifically when molecules are interfaced between proximal electronic probes. The compounds synthesized are series of azobenzenes, bipyridines and oligo(phenylene vinylene)s that bear acetyl-protected thiols for ultimate attachment to metallic surfaces. Some initial electrochemical and solid-state test results are also reported.