5-Methylthiophene-2,3-dicarboxylic Acid

Base Information

• Chemical Name: 5-Methylthiophene-2,3-dicarboxylic Acid
• CAS No.: 46029-22-5
• Molecular Formula: C7H6O4S
• Molecular Weight: 186.18500
• Hs Code.: 2934999090
• Mol file: 46029-22-5.mol

Synonyms:5-Methylthiophene-2,3-dicarboxylicAcid;QC-5992;5-methyl-2,3-thiophenedicarboxylic acid;5-Methyl-thiophen-2,3-dicarbonsaeure;

Chemical Property of 5-Methylthiophene-2,3-dicarboxylic Acid

Chemical Property:

• PSA: 102.84000
• LogP: 1.45290
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-methylthiophene-2,3-dicarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methylthiophene-2,3-dicarboxylic Acid

There total 2 articles about 5-Methylthiophene-2,3-dicarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetonyl-oxalacetic acid diethyl ester (68384-85-0) → 5-methylthiophene-2,3-dicarboxylic acid (46029-22-5)

Guidance literature:

With phosphorous (V) sulfide; toluene; Erhitzen des Reaktionsprodukts mit wss.-aethanol. Natronlauge;

DOI:10.1021/ja01620a031

Reference yield:

2-methylthiophene-5-carboxylic acid (1918-79-2) + carbon dioxide (124-38-9,18923-20-1) → 5-methylthiophene-2,3-dicarboxylic acid (46029-22-5)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF/hexane, -78 deg C, 30 min, 2.) THF/hexane, -78 -> -10 deg C;

DOI:10.3891/acta.chem.scand.51-0392

upstream raw materials:

acetonyl-oxalacetic acid diethyl ester

2-methylthiophene-5-carboxylic acid

carbon dioxide