3-Phenylpropionic acid, 2-tetrahydrofurylmethyl ester

Base Information

• Chemical Name: 3-Phenylpropionic acid, 2-tetrahydrofurylmethyl ester
• CAS No.: 4647-36-3
• Molecular Formula: C14H18O3
• Molecular Weight: 234.29100
• Hs Code.: 2932190090
• Mol file: 4647-36-3.mol

Synonyms:3-phenyl-propionic acid tetrahydrofurfuryl ester;3-PHENYLPROPANOIC ACID 2-TETRAHYDROFURYLMETHYL ESTER;Tetrahydro-2-furanylmethyl 3-phenylpropanoate;3-Phenylpropionic acid,2-tetrahydrofurylmethyl ester;

Chemical Property of 3-Phenylpropionic acid, 2-tetrahydrofurylmethyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.34140

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenylpropionic acid, 2-tetrahydrofurylmethyl ester

There total 3 articles about 3-Phenylpropionic acid, 2-tetrahydrofurylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Tetrahydrofurfuryl alcohol (97-99-4) + 3-Phenylpropionic acid (501-52-0) → (tetrahydrofuran-2-yl)methyl 3-phenyl-propanoate (4647-36-3)

Guidance literature:

With N,N'-dimethylaminopyridine; di-tert-butyl dicarbonate; In nitromethane; at 50 ℃; for 16h;

DOI:10.1055/s-2003-44986

Reference yield: 91.0%

Tetrahydrofurfuryl alcohol (97-99-4) + 3-phenyl-propionaldehyde (104-53-0) → (tetrahydrofuran-2-yl)methyl 3-phenyl-propanoate (4647-36-3)

Guidance literature:

With iodine; potassium carbonate; In tert-butyl alcohol; at 20 ℃; for 22h;

DOI:10.1016/j.tet.2005.03.097

Reference yield:

→ (tetrahydrofuran-2-yl)methyl 3-phenyl-propanoate (4647-36-3)

Guidance literature:

Beim Erhitzen einer Lsg. von Tetrahydrofurfurylalkohol u. 3-Phenyl-propionsaeure in Toluol mit geringen Mengen Toluol-4-sulfonsaeure;

DOI:10.1039/jr9650007162

upstream raw materials:

Tetrahydrofurfuryl alcohol

3-Phenylpropionic acid

3-phenyl-propionaldehyde

Refernces

• 1、 Goo?en, Lukas J.,D?hring, Arno. "A Convenient Protocol for the Esterification of Carboxylic Acids with Alcohols in the Presence of di-t-Butyl Dicarbonate". . p. 263 - 266. Retrieved 2007/10/03.