Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-2-meth yl-

Base Information

Chemical Name:Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-2-meth yl-
CAS No.:4668-07-9
Molecular Formula:C₂₁H₂₇NO₄
Molecular Weight:357.45
Hs Code.:
Mol file:4668-07-9.mol

Synonyms:tetrahydrotakatonine;5,6,7-Trimethoxy-1-(4-methoxy-benzyl)-2-methyl-1,2,3,4-tetrahydro-isochinolin;5,6,7-Trimethoxy-1-(4-methoxy-benzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline;1-(4-Methoxybenzyl)-2-methyl-5,6,7-trimethoxy-1,2,3,4-tetrahydroisochinolin;1-(4-Methoxy-benzyl)-5,6,7-trimethoxy-2-methyl-1,2,3,4-tetrahydro-isochinolin, Tetrahydro-takatonin;Thalifendlerinmethylaether;

Suppliers and Price of Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-2-meth yl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-2-meth yl-

Chemical Property:

Melting Point:195 - 197 °C
PSA：40.16000
LogP:3.43060

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-2-meth yl-

There total 8 articles about Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-2-meth yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 47439-73-6
5,6,7-trimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

: 4668-07-9
(+/-)-tetrahydrotakatonine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaBH₄ / methanol / 1 h / Ambient temperature

2: 2.) POCl₃, 3.) NaBH₄

With sodium tetrahydroborate; trichlorophosphate; In methanol;
DOI:10.1021/jm00090a021

Reference yield:

: 5,6,7-Trimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride

: 4668-07-9
(+/-)-tetrahydrotakatonine

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm00090a021

Reference yield:

: 78478-27-0,5083-09-0
1-(4'-methoxybenzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline

: 4668-07-9
(+/-)-tetrahydrotakatonine

Guidance literature:: Multi-step reaction with 3 steps

1: Ambient temperature

2: POCl₃ / toluene / 3 h / Heating

3: NaBH₄ / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; trichlorophosphate; In methanol; toluene;
DOI:10.1021/jm00090a021