5,6,7-Trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:5,6,7-Trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
CAS No.:78478-27-0
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:
DSSTox Substance ID:DTXSID30999791
Nikkaji Number:J2.395.801E,J490.028F
Wikidata:Q82993071
Metabolomics Workbench ID:44294
ChEMBL ID:CHEMBL74793

Synonyms:Anomurine;78478-27-0;5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 1,2,3,4-tetrahydro-5,6,7-trimethoxy-1-((4-methoxyphenyl)methyl)-;(+)-Anomurine;CHEMBL74793;SCHEMBL9186941;DTXSID30999791;CHEBI:174630;1,2,3,4-Tetrahydro-5,6,7-trimethoxy-1-(4-methoxybenzyl)isoquinoline;1,2,3,4-Tetrahydro-5,6,7-trimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline, 9CI

Suppliers and Price of 5,6,7-Trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5,6,7-Trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Vapor Pressure:2.07E-09mmHg at 25°C
Boiling Point:481°Cat760mmHg
Flash Point:204.3°C
PSA：48.95000
Density:1.12g/cm³
LogP:3.47930
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:343.17835828
Heavy Atom Count:25
Complexity:399

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CC2C3=CC(=C(C(=C3CCN2)OC)OC)OC

Technology Process of 5,6,7-Trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about 5,6,7-Trimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 47439-73-6
5,6,7-trimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

: 78478-27-0,5083-09-0
1-(4'-methoxybenzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00090a021

Reference yield: 96.0%

: 78478-27-0,5083-09-0
1-(4'-methoxybenzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

Reference yield:

: 78478-27-0,5083-09-0
1-(4'-methoxybenzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline

: 4668-07-9
(+/-)-tetrahydrotakatonine

Guidance literature:: Multi-step reaction with 3 steps

1: Ambient temperature

2: POCl₃ / toluene / 3 h / Heating

3: NaBH₄ / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; trichlorophosphate; In methanol; toluene;
DOI:10.1021/jm00090a021