Technology Process of Bicyclo[3.2.1]octan-2-one,
4-ethenyl-7-(methoxymethoxy)-4-[(phenylmethoxy)methyl]-,
(1R,4R,5S,7S)-
There total 4 articles about Bicyclo[3.2.1]octan-2-one,
4-ethenyl-7-(methoxymethoxy)-4-[(phenylmethoxy)methyl]-,
(1R,4R,5S,7S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
vinylmagnesium chloride;
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran;
(1R,5S,7S)-4-Benzyloxymethyl-7-methoxymethoxy-bicyclo[3.2.1]oct-3-en-2-one;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane;
In
tetrahydrofuran;
at -78 ℃;
With
tetrabutyl ammonium fluoride;
DOI:10.1055/s-2002-32603
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 95 percent / BuLi / tetrahydrofuran / -78 °C
2.1: 75 percent / PCC / CH2Cl2
3.1: CuBr*Me2S / tetrahydrofuran
3.2: HMPA; TMS-Cl / tetrahydrofuran / -78 °C
3.3: 92 percent / TBAF
With
n-butyllithium; copper(I) bromide dimethylsulfide complex; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2002-32603
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 95 percent / BuLi / tetrahydrofuran / -78 °C
2.1: 75 percent / PCC / CH2Cl2
3.1: CuBr*Me2S / tetrahydrofuran
3.2: HMPA; TMS-Cl / tetrahydrofuran / -78 °C
3.3: 92 percent / TBAF
With
n-butyllithium; copper(I) bromide dimethylsulfide complex; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2002-32603
