schinifoline

Base Information

• Chemical Name: schinifoline
• CAS No.: 80554-58-1
• Molecular Formula: C17H23NO
• Molecular Weight: 257.3706
• Mol file: 80554-58-1.mol

Synonyms:1-Methyl-2-heptyl-4(1H)-quinolinone;4(1H)-Quinolinone,2-heptyl-1-methyl-;Schinifoline;Schinifoline (C17 alkaloid);2-heptyl-1-methyl-quinolin-4-one;

Chemical Property of schinifoline

Chemical Property:

• Vapor Pressure: 1.91E-05mmHg at 25°C
• Melting Point: 82-83 °C
• Refractive Index: 1.53
• Boiling Point: 362.6 °C at 760 mmHg
• PKA: 2.59±0.70(Predicted)
• Flash Point: 124 °C
• PSA: 22.00000
• Density: 1.008 g/cm³
• LogP: 4.05140

Purity/Quality:

98%min ^*data from raw suppliers

Schinifoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of schinifoline

There total 9 articles about schinifoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-heptyl-quinolin-4(1H)-one (40522-46-1) + dimethyl sulfate (77-78-1) → schinifoline (80554-58-1)

Guidance literature:

2-heptyl-quinolin-4(1H)-one; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.75h;

dimethyl sulfate; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 14h;

DOI:10.3762/bjoc.15.18

Reference yield: 10.0%

2-heptyl-quinolin-4(1H)-one (40522-46-1) + methyl iodide (74-88-4) → 2-heptyl-4-methoxyquinoline (80554-59-2) + schinifoline (80554-58-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1002/jhet.5570180603

Reference yield: 5.8%

N-methylanthraniloyl-coenzyme A + β-ketodecanoic acid (13283-92-6) + S-(hydrogen malonyl)coenzyme A (524-14-1) → schinifoline (80554-58-1)

Guidance literature:

With Huperzia serrata type III polyketide synthase; In aq. phosphate buffer; dimethyl sulfoxide; at 37 ℃; for 12h; pH=7; Enzymatic reaction;

DOI:10.1021/acs.orglett.6b01501

upstream raw materials:

2-heptyl-quinolin-4(1H)-one

methyl iodide

ethyl 3-oxodecanoate

2-acetyl-3-oxo-decanoic acid ethyl ester