L-Lysine dihydrochloride

Base Information

• Chemical Name: L-Lysine dihydrochloride
• CAS No.: 657-26-1
• Molecular Formula: C6H16Cl2N2O2
• Molecular Weight: 219.111
• Hs Code.: 29224190
• Mol file: 657-26-1.mol

Synonyms:L-Lysine,dihydrochloride (9CI);Lysine, dihydrochloride, L- (8CI);Lysinedihydrochloride;H-Lys-OH.2HCl;H-Lys-OH·2HCl;

Chemical Property of L-Lysine dihydrochloride

Chemical Property:

• Appearance/Colour: white to very light yellow crystalline powder
• Melting Point: 200-206 °C(lit.)
• Refractive Index: 15 ° (C=2, H2O)
• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 142.2 °C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water (100 mg/ml).
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 182.0822054
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

99% ^*data from raw suppliers

L-Lysine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CCN)CC(C(=O)O)[NH3+].[Cl-]
• Isomeric SMILES: C(CCN)C[C@@H](C(=O)O)[NH3+].[Cl-]
• Uses: Synthesis of hyperbranched polylysine using the N-hydroxysuccinimide ester of L-lysine dihydrochloride as AB 2 building block. The histidine and lysine standards were prepared from L-histidine monohydro- chloride and L-lysine dihydrochloride respectively. L-Homocitrulline-The copper complex was prepared from L-lysine dihydrochloride in 80 to 86 per cent yields.

Technology Process of L-Lysine dihydrochloride

There total 5 articles about L-Lysine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-Lys(Boc)-OH (2483-46-7) → L-lysine dihydrochloride (657-26-1,26124-78-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 24h;

DOI:10.1002/chem.201902556

Reference yield: 94.6%

D-lysine (923-27-3,3506-25-0) → D-lysine bis(hydrochloride) (70-53-1,617-68-5,657-26-1,657-27-2,7274-88-6,10098-89-2,10303-72-7,22834-80-6,28826-16-6,42334-88-3,68147-44-4,94706-35-1,26124-78-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 3h;

DOI:10.1021/acs.orglett.8b02619

Reference yield: 93.9%

L-lysine (56-87-1,3506-25-0) → L-lysine dihydrochloride (657-26-1,26124-78-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 3h;

DOI:10.1021/acs.orglett.8b02619

upstream raw materials:

N_α,N_ε-di-Boc-L-lysine p-nitrophenyl ester

L-lysine

Boc-Lys(Boc)-OH

D-lysine

Downstream raw materials:

2,6-Diamino-hexanoic acid; hydrochloride

N-(fluorenyl-9-methoxycarbonyl)-L-lysine

(2,3,4,5,6-pentafluorophenyl)methanol

4-fluorobenzylic alcohol

Refernces

• 1、 Heilmann, Michael,Tiefenbacher, Konrad. "A Modular Phosphorylated Glycoluril-Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines". supporting information. p. 12900 - 12904. Retrieved 2019/11/05.
• 2、 Burakowski, Andrzej,Gliński, Jacek. "Hydration of amino acids from ultrasonic measurements". experimental part. p. 12157 - 12161. Retrieved 2011/01/11.