Pentanedioic acid, 2-bromo-4-methyl-, dimethyl ester (9CI)

Base Information

• Chemical Name: Pentanedioic acid, 2-bromo-4-methyl-, dimethyl ester (9CI)
• CAS No.: 474327-99-6
• Molecular Formula: C8H13BrO4
• Molecular Weight: 253.09000
• Mol file: 474327-99-6.mol

Synonyms:2-Bromo-4-methyl-pentanedioic acid dimethyl ester;2-Brom-4-methyl-glutarsaeure-dimethylester;

Chemical Property of Pentanedioic acid, 2-bromo-4-methyl-, dimethyl ester (9CI)

Chemical Property:

• Boiling Point: 75 °C (1 mmHg)
• PSA: 52.60000
• LogP: 1.12210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanedioic acid, 2-bromo-4-methyl-, dimethyl ester (9CI)

There total 2 articles about Pentanedioic acid, 2-bromo-4-methyl-, dimethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

Methyl 2-bromopropionate (5445-17-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2-bromo-4-methyl-glutaric acid dimethyl ester (474327-99-6)

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(I) bromide; copper(ll) bromide; In acetone; at 35 ℃; for 2h;

DOI:10.1021/ma035516s

Reference yield:

2-methylglutaric acid (18069-17-5) → 2-bromo-4-methyl-glutaric acid dimethyl ester (474327-99-6)

Guidance literature:

With thionyl chloride; man setzt bei 40grad Brom hinzu, erwaermt die Reaktions-Loesung dann auf 60grad und giesst das Reaktionsprodukt in Methanol;

Reference yield: 14.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 2-bromo-4-methyl-glutaric acid dimethyl ester (474327-99-6) → C16H21BrO4

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(I) bromide; In toluene; for 2h; Heating;

DOI:10.1021/jacs.5b11631

upstream raw materials:

2-methylglutaric acid

Methyl 2-bromopropionate

acrylic acid methyl ester

Refernces

• 1、 Kajiwara, Atsushi,Nanda, Ajaya Kumar,Matyjaszewski, Krzysztof. "Electron Spin Resonance Study of Monomeric, Dimeric, and Polymeric Acrylate Radicals Prepared Using the Atom Transfer Radical Polymerization Technique - Direct Detection of Penultimate-Unit Effects". . p. 1378 - 1385. Retrieved 2007/10/03.