18069-17-5Relevant articles and documents
Metabolism of drugs. XXIX. Metabolic fate of meprobamate. 2. Further studies on the structure of the metabolites.
YAMAMOTO,YOSHIMURA,TSUKAMOTO
, p. 540 - 544 (1962)
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Sustainable electroorganic synthesis of lignin-derived dicarboxylic acids
Rauen, Anna Lisa,Waldvogel, Siegfried R.,Weinelt, Frank
supporting information, p. 5956 - 5960 (2020/10/18)
The oxidative ring opening of lignin-derived alkylated cyclohexanols to bio-based alkylated dicarboxylic acids is successfully performed by an electrocatalytic conversion. To establish this transformation as a green method, we developed a simple protocol for the anodic oxidation at nickel oxide-hydroxide (NiOOH) foam anodes in caustic soda in both a batch and flow electrolysis approach.
Method used for synthesis of 2-methylpentanedioic acid dimethyl ester
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Paragraph 0037-0042; 0044-0049; 0051-0056, (2019/06/30)
The invention provides a method used for synthesis of 2-methylpentanedioic acid dimethyl ester. The method used for synthesis of 2-methylpentanedioic acid dimethyl ester comprises following steps: 2-methyl pentanedinitrile is mixed with an acid, hydrolysis reaction is carried out, an obtained product is allowed to stand so as to obtain an upper layer oil phase and a lower layer water phase; the oil phase and the water phase are separated; the oil phase is mixed with methanol for esterification reaction so as to obtain 2-methylpentanedioic acid dimethyl ester. Operation of the method is simple;technology route is short; raw material consumption is low; and no waste gas, waste water, or waste residue is generated.
Palladium Complexes with Bulky Diphosphine Ligands as Highly Selective Catalysts for the Synthesis of (Bio-) Adipic Acid from Pentenoic Acid Mixtures.
Low, Choon Heng,Nobbs, James D.,Van Meurs, Martin,Stubbs, Ludger P.,Drent, Eite,Aitipamula, Srinivasulu,Pung, Michelle H. L.
, p. 4281 - 4292 (2015/09/22)
A series of sterically bulky diphosphines have been prepared, including P2 = trans-1,2-bis[(di-tert-butylphosphino)methyl]cyclohexane (4), (2-methylenepropane-1,3-diyl)bis(di-tert-butylphosphine) (5), bis[(di-tert-butylphosphino)methyl]dimethylsilane (6), and cis- and trans-11,12-bis[(di-tert-butylphosphino)methyl]-9,10-dihydro-9,10-ethanoanthracene (10 and 11). The corresponding palladium complexes of these ligands, P2Pd(CF3CO2)2, have been synthesized and characterized. The solid-state structures of [Pd(4)(CF3CO2)2], [Pd(5)(CF3CO2)2], [Pd(6)(CF3CO2)2], and [Pd(11)(CF3CO2)2] were obtained by single-crystal X-ray diffraction and confirm the bidentate binding mode of the ligand and a square-planar coordination geometry with a minor distortion from the ideal. The diphosphines in combination with Pd(OAc)2 have been applied in the hydroxycarbonylation of a mixture of pentenoic acid isomers to produce adipic acid with high selectivity (in several cases >95%). The (regio)selectivity of the hydroxycarbonylation reaction is highly dependent on the P2 diphosphine ligand structure, particularly the steric bulk of the substituents on the diphosphine donor and the P-Pd-P bite angle in the complexes, with respectively tertiary alkyl phosphine substituents (tert-butyl, adamantyl) and a C4 backbone P-Pd-P bite angle >100° being the common features of highly adipic acid selective systems. It is suggested that the regioselectivity of hydroxycarbonylation becomes largely driven by the chelation of the carboxylic acid functionality of pentenoic acid substrates, when smaller size P substituents and/or when P2 ligands with smaller bite angles (100°) are applied.