Quinoline, 6-bromo-4-(4-morpholinyl)-

Base Information

• Chemical Name: Quinoline, 6-bromo-4-(4-morpholinyl)-
• CAS No.: 474707-20-5
• Molecular Formula: C13H13BrN2O
• Molecular Weight: 293.15900
• Mol file: 474707-20-5.mol

Synonyms:4-(6-Bromo-4-quinolyl)-morpholine;4-(6-bromoquinolin-4-yl)morpholine;6-bromo-4-morpholin-4-yl-quinoline;4-(6-bromo-4-quinolyl)morpholine;

Chemical Property of Quinoline, 6-bromo-4-(4-morpholinyl)-

Chemical Property:

• Melting Point: 72 - 73 °C
• PSA: 25.36000
• LogP: 2.89890

Purity/Quality:

4-(6-Bromoquinolin-4-yl)morpholine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline, 6-bromo-4-(4-morpholinyl)-

There total 3 articles about Quinoline, 6-bromo-4-(4-morpholinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + 6-bromo-4-chloroquinoline (65340-70-7) → 6-bromo-4-(morpholin-4-yl)quinoline (474707-20-5)

Guidance literature:

at 60 - 90 ℃;

DOI:10.1021/jm200386s

Reference yield:

6-bromoquinolin-4-ol (145369-94-4) → 6-bromo-4-(morpholin-4-yl)quinoline (474707-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 6 h / Reflux; Inert atmosphere

2: isopropyl alcohol / 1 h / Reflux; Inert atmosphere

With trichlorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.ejmech.2014.01.053

Reference yield:

→ 6-bromo-4-(morpholin-4-yl)quinoline (474707-20-5)

Guidance literature:

upstream raw materials:

morpholine

6-bromo-4-chloroquinoline

6-bromoquinolin-4-ol

Downstream raw materials:

2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)-2-fluorobenzenesulfonamide

N-(2-chloro-5-(4-morpholinoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

3-(2,4-difluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinolin-6-yl)benzamide

Refernces

• 1、 Han, Jinsong,Chen, Ying,Yang, Chao,Liu, Ting,Wang, Mingping,Xu, Haojie,Zhang, Ling,Zheng, Canhui,Song, Yunlong,Zhu, Ju. "Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor". . p. 684 - 701. Retrieved 2016/07/21.
• 2、 -. "2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE". Paragraph 1287. . Retrieved 2015/11/27.