2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

Base Information

Chemical Name:2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide
CAS No.:1201842-32-1
Molecular Formula:C₂₄H₁₉Cl₃N₄O₃S
Molecular Weight:549.865
Hs Code.:

Synonyms:2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

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Chemical Property of 2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

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Technology Process of 2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

There total 5 articles about 2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6579-54-0
2,6-dichlorobenzenesulfonyl chloride

: 1201844-96-3
2-chloro-5-(4-morpholinoquinolin-6-yl)pyridin-3-amine

: 1201842-32-1
2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

Guidance literature:: 2-chloro-5-(4-morpholinoquinolin-6-yl)pyridin-3-amine; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

2,6-dichlorobenzenesulfonyl chloride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1201842-32-1
2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.33 h / 110 °C / Inert atmosphere; microwave irradiation

2.1: sodium carbonate / Pd-fibrecat / 1,4-dioxane / 0.33 h / 130 °C / microwave irradiation

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C

With potassium acetate; sodium hexamethyldisilazane; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 65340-70-7
6-bromo-4-chloroquinoline

: 1201842-32-1
2,6-dichloro-N-(2-chloro-5-(4-(4-morpholinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 1.5 h / 90 °C

2.1: sodium carbonate / Pd-fibrecat / 1,4-dioxane / 0.33 h / 130 °C / microwave irradiation

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C

With sodium hexamethyldisilazane; sodium carbonate; Pd-fibrecat; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;