(R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

Base Information

Chemical Name:(R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid
CAS No.:474902-30-2
Molecular Formula:C12H11NO4
Molecular Weight:233.224
Hs Code.:
DSSTox Substance ID:DTXSID40446120
Wikidata:Q82264701
Mol file:474902-30-2.mol

Synonyms:474902-30-2;(R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid;CTK1C7242;DTXSID40446120

Suppliers and Price of (R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:233.06880783
Heavy Atom Count:17
Complexity:366

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(=O)N(C1=O)C2=CC=CC=C2C(=O)O
Isomeric SMILES:C[C@@H]1CC(=O)N(C1=O)C2=CC=CC=C2C(=O)O

Technology Process of (R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

There total 2 articles about (R)-2-(3-Methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 83247-83-0
(R)-(+)-3-methyldihydrofuran-2,5-dione

: 474902-30-2
(R)-2-(methylsuccinimido)benzoic acid

Guidance literature:: at 145 ℃; for 3h; under 0.1 Torr;
DOI:10.1016/S0223-5234(02)01353-3

Reference yield:

: 3641-51-8
2-(R)-methylsuccinic acid

: 474902-30-2
(R)-2-(methylsuccinimido)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic anhydride; pyridine

2.1: CHCl₃ / 0.5 h / Heating

2.2: 0.9 g / triethylamine / toluene / 12 h / Heating

With pyridine; acetic anhydride; In chloroform;
DOI:10.1016/j.bmc.2006.10.061

Reference yield: 73.6%

: 474902-30-2
(R)-2-(methylsuccinimido)benzoic acid

: 474902-32-4
(R)-3-hydroxymethyl-N-(3-phenyl)propylpiperidine

: 2-((R)-3-Methyl-2,5-dioxo-pyrrolidin-1-yl)-benzoic acid (R)-1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1016/S0223-5234(02)01353-3