2-Bromo-4,5-difluorobenzaldehyde

Base Information

• Chemical Name: 2-Bromo-4,5-difluorobenzaldehyde
• CAS No.: 476620-54-9
• Molecular Formula: C7H3BrF2O
• Molecular Weight: 221.001
• Hs Code.: 2913000090
• Mol file: 476620-54-9.mol

Synonyms:2-bromo-4,5-difluoro-benzaldehyde;

Chemical Property of 2-Bromo-4,5-difluorobenzaldehyde

Chemical Property:

• Boiling Point: 232.0±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.758±0.06 g/cm3(Predicted)
• LogP: 2.53980
• Storage Temp.: Room temperature.
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99.00% ^*data from raw suppliers

2-Bromo-4,5-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is an important intermediate for pharmaceutical and organic synthesis.

Technology Process of 2-Bromo-4,5-difluorobenzaldehyde

There total 3 articles about 2-Bromo-4,5-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(2-bromo-4,5-difluorophenyl)methanol (476620-55-0) → 2-bromo-4,5-difluorobenzaldehyde (476620-54-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 50.0%

1,2-difluoro-4,5-dibromobenzene (64695-78-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-4,5-difluorobenzaldehyde (476620-54-9)

Guidance literature:

1,2-difluoro-4,5-dibromobenzene; With n-butyllithium; In tetrahydrofuran; at -110 ℃; for 0.75h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -110 ℃; for 0.25h;

With sulfuric acid; In tetrahydrofuran; water; at -50 ℃;

DOI:10.1002/ejoc.201601328

Reference yield:

2-bromo-4,5-difluorobenzoic acid (64695-84-7) → 2-bromo-4,5-difluorobenzaldehyde (476620-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / Reflux

2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With dimethylsulfide borane complex; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(2-bromo-4,5-difluorophenyl)methanol

2-bromo-4,5-difluorobenzoic acid

1,2-difluoro-4,5-dibromobenzene

N,N-dimethyl-formamide

Downstream raw materials:

2-(2-bromo-4,5-difluorophenyl)-1,3-dioxane

1-bromo-4,5-difluoro-2-(dimethoxymethyl)benzene

Refernces

• 1、 -. "PRMT5 INHIBITORS". Page/Page column 76-77. . Retrieved 2020/12/30.
• 2、 Lacombe, Patrick,Arbour, Mélissa,Aspiotis, Renée,Cauchon, Elizabeth,Chen, Austin,Dubé, Daniel,Falgueyret, Jean-Pierre,Fournier, Pierre-André,Gallant, Michel,Grimm, Erich,Han, Yongxin,Juteau, Hélne,Liu, Suzanna,Mellon, Christophe,Ramtohul, Yeeman,Simard, Daniel,St-Jacques, René,Tsui, Gavin Chit. "3,4-Diarylpiperidines as potent renin inhibitors". scheme or table. p. 1953 - 1957. Retrieved 2012/04/04.