Desoxymorphine-C

Base Information

• Chemical Name: Desoxymorphine-C
• CAS No.: 63732-65-0
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.3383
• DSSTox Substance ID: DTXSID20213170
• Nikkaji Number: J72.593E
• Wikidata: Q76311087
• Metabolomics Workbench ID: 144072
• Mol file: 63732-65-0.mol

Synonyms:Desoxymorphine-C;Desoxymorphine C;BRN 0102234;63732-65-0;Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-;2-27-00-00080 (Beilstein Handbook Reference);Desoxymorphin;DTXSID20213170;LS-91939;6,7-Didehydro-4,5alpha-epoxy-17-methylmorphinan-3-ol;Morphinan-3-ol, 6,7-didehydro-4,5-epoxy-17-methyl-, (5.alpha.)-

Chemical Property of Desoxymorphine-C

Chemical Property:

• Vapor Pressure: 1.74E-07mmHg at 25°C
• Boiling Point: 415.3°Cat760mmHg
• Flash Point: 204.9°C
• PSA: 32.70000
• Density: 1.34g/cm³
• LogP: 2.16520
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 269.141578849
• Heavy Atom Count: 20
• Complexity: 464

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C=CC4
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C=CC4

Technology Process of Desoxymorphine-C

There total 4 articles about Desoxymorphine-C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

codeine (76-57-3) → desoxymorphine C (63732-65-0) + C17H18BrNO2*BrH

Guidance literature:

With acetic acid; at 100 ℃; for 5h; under 1034.32 Torr;

DOI:10.1021/jo0206871

Reference yield:

→ 4,5-epoxy-17-methyl-morphin-6-en-3-ol (63732-65-0)

Guidance literature:

With sodium methylate; at 140 ℃; im Rohr;

DOI:10.1021/ja01334a042

Reference yield:

6β-chloro-4,5α-epoxy-17-methyl-morphinan-3-ol (59971-06-1) → desoxymorphine C (63732-65-0)

Guidance literature:

With sodium methylate;

DOI:10.1021/ja01334a042

upstream raw materials:

6β-chloro-4,5α-epoxy-17-methyl-morphinan-3-ol

codeine

Downstream raw materials:

17-methyl-morphinane-3,4-diol