Chlorodihydromorphide

Base Information

• Chemical Name: Chlorodihydromorphide
• CAS No.: 59971-06-1
• Molecular Formula: C17H20ClNO2
• Molecular Weight: 305.7992
• DSSTox Substance ID: DTXSID00975401
• Nikkaji Number: J66.325E
• Wikidata: Q76311026
• Mol file: 59971-06-1.mol

Synonyms:Chlorodihydromorphide;Morphide, chlorodihydro-;BRN 0102242;59971-06-1;Morphinan-3-ol, 6-alpha-chloro-4,5-alpha-epoxy-17-methyl-;2-27-00-00077 (Beilstein Handbook Reference);C17H20ClNO2;DTXSID00975401;LS-91886;6-Chloro-17-methyl-4,5-epoxymorphinan-3-ol;6alpha-Chloro-4,5alpha-epoxy-17-methylmorphinan-3-ol;Morphinan-3-ol, 6-chloro-4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)-

Chemical Property of Chlorodihydromorphide

Chemical Property:

• Vapor Pressure: 2.11E-09mmHg at 25°C
• Boiling Point: 468.5°C at 760 mmHg
• Flash Point: 237.2°C
• PSA: 32.70000
• Density: 1.4g/cm³
• LogP: 2.60650
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 305.1182566
• Heavy Atom Count: 21
• Complexity: 460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(CC4)Cl
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](CC4)Cl

Technology Process of Chlorodihydromorphide

There total 2 articles about Chlorodihydromorphide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-chloro-4,5-epoxy-17-methyl-morphinan-3-ol (59971-06-1)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja01334a042

Reference yield:

→ 6-chloro-4,5-epoxy-17-methyl-morphinan-3-ol (59971-06-1)

Guidance literature:

With phosphorus; hydrogen iodide;

Reference yield:

6β-chloro-4,5α-epoxy-17-methyl-morphinan-3-ol (59971-06-1) → desoxymorphine C (63732-65-0)

Guidance literature:

With sodium methylate;

DOI:10.1021/ja01334a042

Downstream raw materials:

desoxymorphine C