Technology Process of 2,6-Heptadienoic acid, 3,5-dimethoxy-4-methyl-7-phenyl-, methyl ester,
(2E,4R,5S,6E)-
There total 11 articles about 2,6-Heptadienoic acid, 3,5-dimethoxy-4-methyl-7-phenyl-, methyl ester,
(2E,4R,5S,6E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(+)-E-(2R,3S)-5-methoxy-4-methyl-3-oxo-7-phenyl-hept-6-enoic acid methyl ester;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride;
In
various solvent(s);
at 0 ℃;
dimethyl sulfate;
In
various solvent(s);
at 20 ℃;
for 24h;
Further stages.;
DOI:10.1039/b603433k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-Bu2BOTf; Et3N / CH2Cl2 / 1 h / 0 °C
1.2: CH2Cl2 / 2.33 h / -78 - 0 °C
1.3: 90 percent / aq. H2O2 / CH2Cl2; methanol / 10 °C
2.1: 72 percent / 2,6-di-tert-butylpyridine / CH2Cl2 / 40 h / 20 °C
3.1: 80 percent / aq. H2O2; LiOH / tetrahydrofuran / 4 h / 0 °C
4.1: LDA / tetrahydrofuran / -78 °C
4.2: N,N'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C
4.3: 85 percent / tetrahydrofuran / 3 h / -78 - 0 °C
5.1: NaH; N,N'-dimethylpropylene urea / various solvent(s) / 0 °C
5.2: 66 percent / various solvent(s) / 24 h / 20 °C
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; 2,6-di-tert-butyl-pyridine; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; sodium hydride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
1.2: Evans aldol reaction;
DOI:10.1039/b603433k
