Ciglitazone

Base Information Edit

Chemical Name:Ciglitazone
CAS No.:74772-77-3
Molecular Formula:C₁₈H₂₃NO₃S
Molecular Weight:333.452
Hs Code.:29341000
European Community (EC) Number:692-459-4
UNII:U8QXS1WU8G
DSSTox Substance ID:DTXSID0040757
Nikkaji Number:J20.561C
Wikipedia:Ciglitazone
Wikidata:Q5119890
NCI Thesaurus Code:C72726
Pharos Ligand ID:ZJRNRNJKS7TW
Metabolomics Workbench ID:63254
ChEMBL ID:CHEMBL7002
Mol file:74772-77-3.mol

Synonyms:5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione;ADD 3878;ADD-3878;ciglitazone;ciglitizone

Suppliers and Price of Ciglitazone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ciglitazone
5mg
$ 350.00

Usbiological
Ciglitazone
1mg
$ 273.00

TRC
Ciglitazone
5mg
$ 80.00

TRC
Ciglitazone
10mg
$ 140.00

Tocris
Ciglitazone ≥99%(HPLC)
50
$ 878.00

Tocris
Ciglitazone ≥99%(HPLC)
10
$ 214.00

Sigma-Aldrich
Ciglitazone
5mg
$ 161.87

Sigma-Aldrich
Ciglitizone ≥98% (HPLC)
5mg
$ 308.00

Medical Isotopes, Inc.
Ciglitazone
10 mg
$ 830.00

CSNpharm
Ciglitazone
25mg
$ 240.00

Total 18 raw suppliers

Chemical Property of Ciglitazone Edit

Chemical Property:

Appearance/Colour:white cyrstalline solid
Vapor Pressure:2.65E-10mmHg at 25°C
Melting Point:130-131 °C
Refractive Index:1.568
Boiling Point:504.5 °C at 760 mmHg
PKA:6.36±0.50(Predicted)
Flash Point:258.9 °C
PSA：80.70000
Density:1.189 g/cm³
LogP:4.25870
Storage Temp.:Store at RT
Solubility.:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:333.13986477
Heavy Atom Count:23
Complexity:440

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ciglitazone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Description Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable.
Uses Displays antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist Displays antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist. Ciglitizone has been used as a proliferator-activated receptor γ (PPARγ) agonist:to study its effects on cell proliferation in human melanocytesto study its effects on pigmentation and migration of human melanocytesIt also may be used to study its effects on cell cycle and apoptosis in monocytic cells.

Technology Process of Ciglitazone

There total 11 articles about Ciglitazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: 85010-66-8
2-imino-5-<4-(1-methylcyclohexylmethoxy)benzyl>thiazolidin-4-one

: 96207-23-7,96207-25-9,74772-77-3
Ciglitazone

Guidance literature:: With hydrogenchloride; In 2-methoxy-ethanol; for 6h; Heating;
DOI:10.1248/cpb.30.3580

Reference yield: 80.0%

: 196079-42-2
Δ2CG

: 96207-23-7,96207-25-9,74772-77-3
Ciglitazone

Guidance literature:: Δ2CG; With sodium tetrahydroborate; water; butane-2,3-dione dioxime; sodium hydroxide; cobalt(II) chloride hexahydrate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

With acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; pH=6;