Technology Process of L-Glutamic acid,
N-[4-[(2,4-diamino-8,9-dihydropyrimido[4,5-b][1,6]naphthyridin-7(6H)-yl
)methyl]benzoyl]-, diethyl ester
There total 12 articles about L-Glutamic acid,
N-[4-[(2,4-diamino-8,9-dihydropyrimido[4,5-b][1,6]naphthyridin-7(6H)-yl
)methyl]benzoyl]-, diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: p-toluenesulfonic acid / benzene / Heating
2.1: triethylamine / tetrahydrofuran / 1.5 h / -40 - 20 °C
3.1: 4.6 g / NH3 / methanol / 20 °C
4.1: potassium tert-butoxide / dimethylformamide / 1 h / 20 °C
4.2: 78 percent / dimethylformamide / 100 °C
5.1: 82 percent / 40percent KOH / methanol / 2 h / Heating
6.1: 60 percent / 4-N,N-dimethylaminopyridine; triethylamine / dimethylformamide / 60 - 80 °C
7.1: 85 percent / 2 N NaOH / methanol; dimethylsulfoxide / 16 h / 20 °C
8.1: triethylamine / dimethylformamide / 0.5 h / 0 °C
9.1: 120 mg / triethylamine / dimethylformamide / 20 °C
With
dmap; sodium hydroxide; potassium tert-butylate; ammonia; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm0202369
- Guidance literature:
-
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1021/jm0202369
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: p-toluenesulfonic acid / benzene / Heating
2.1: triethylamine / tetrahydrofuran / 1.5 h / -40 - 20 °C
3.1: 2.4 g / NH3 / methanol / 20 °C
4.1: potassium tert-butoxide / dimethylformamide / 1 h / 20 °C
4.2: 63 percent / dimethylformamide / 100 °C
5.1: 30percent KOH / methanol / Heating
6.1: 60 percent / 4-N,N-dimethylaminopyridine; triethylamine / dimethylformamide / 60 - 80 °C
7.1: 85 percent / 2 N NaOH / methanol; dimethylsulfoxide / 16 h / 20 °C
8.1: triethylamine / dimethylformamide / 0.5 h / 0 °C
9.1: 120 mg / triethylamine / dimethylformamide / 20 °C
With
dmap; sodium hydroxide; potassium tert-butylate; ammonia; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm0202369
