2-METHYL-N-[4-METHYL-3-(4-PIPERIDINYL)PHENYL]PROPANAMIDE

Base Information

• Chemical Name: 2-METHYL-N-[4-METHYL-3-(4-PIPERIDINYL)PHENYL]PROPANAMIDE
• CAS No.: 486451-46-1
• Molecular Formula: C16H24N2O
• Molecular Weight: 260.379
• Mol file: 486451-46-1.mol

Synonyms:2-METHYL-N-[4-METHYL-3-(4-PIPERIDINYL)PHENYL]PROPANAMIDE;2-methyl-N-(4-methyl-3-(4-piperidyl)phenyl)propanamide;2-methyl-N-(4-methyl-3-(4-piperidyl)phenyl)-propanamide;

Chemical Property of 2-METHYL-N-[4-METHYL-3-(4-PIPERIDINYL)PHENYL]PROPANAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• PSA: 41.13000
• LogP: 3.45830

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-N-[4-METHYL-3-(4-PIPERIDINYL)PHENYL]PROPANAMIDE

There total 6 articles about 2-METHYL-N-[4-METHYL-3-(4-PIPERIDINYL)PHENYL]PROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(5-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester (487057-87-4) → 2-methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide (486451-46-1)

Guidance literature:

4-(5-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With potassium hydroxide; In chloroform; water; isopropyl alcohol;

Reference yield:

N-(3-iodo-4-methylphenyl)isobutyramide (949096-68-8) → 2-methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide (486451-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

2: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

3: HCl / dioxane / 1 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1021/jm060381c

Reference yield:

4-(5-isobutyrylamino-2-methylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (487057-86-3) → 2-methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide (486451-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

2: HCl / dioxane / 1 h / 20 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate;

DOI:10.1021/jm060381c

upstream raw materials:

4-(5-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester

N-(3-iodo-4-methylphenyl)isobutyramide

4-(5-isobutyrylamino-2-methylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

3-iodo-4-methylaniline

Downstream raw materials:

N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

SNAP 94847

N-{3-[1-(3-aminopropyl)piperidin-4-yl]-4-methylphenyl}isobutyramide