N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

Base Information

Chemical Name:N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide
CAS No.:949096-76-8
Molecular Formula:C₂₇H₃₃N₃O₃
Molecular Weight:447.577
Hs Code.:

Synonyms:N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

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Chemical Property of N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

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Technology Process of N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

There total 6 articles about N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949096-68-8
N-(3-iodo-4-methylphenyl)isobutyramide

: 949096-76-8
N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

2: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

3: HCl / dioxane / 1 h / 20 °C

4: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm060381c

Reference yield:

: 487057-86-3
4-(5-isobutyrylamino-2-methylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 949096-76-8
N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

2: HCl / dioxane / 1 h / 20 °C

3: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1021/jm060381c

Reference yield:

: 35944-64-0
3-iodo-4-methylaniline

: 949096-76-8
N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-4-methylphenyl)isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / tetrahydrofuran / 2 h / 20 °C

2: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

3: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

4: HCl / dioxane / 1 h / 20 °C

5: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm060381c