4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine

Base Information

• Chemical Name: 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine
• CAS No.: 501358-54-9
• Molecular Formula: C5H2Cl2N4
• Molecular Weight: 189.004
• Mol file: 501358-54-9.mol

Synonyms:

Chemical Property of 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine

Chemical Property:

• PSA: 54.46000
• LogP: 1.65970

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine

There total 4 articles about 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-diamino-2,6-dichloropyridine (101079-63-4) → 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine (501358-54-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.0833333h;

Reference yield: 95.0%

3,4-diamino-2,6-dichloropyridine dihydrochloride → 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine (501358-54-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.0833333h;

DOI:10.1016/j.bmcl.2011.05.093

Reference yield:

2,6-dichloro-[4]pyridylamine (2587-02-2) → 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine (501358-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 0 - 10 °C

1.2: 2.5 h / -5 - 0 °C

1.3: 0.17 h / 20 °C / pH 9.5 / Cooling with ice

2.1: hydrogen / ethanol / 16 h / 20 °C / 760.05 Torr

3.1: hydrogenchloride; sodium nitrite / water / 0.08 h / 0 °C

With hydrogenchloride; sulfuric acid; hydrogen; sodium nitrite; In ethanol; water;

DOI:10.1021/acs.jmedchem.1c01132

upstream raw materials:

3,4-diamino-2,6-dichloropyridine

2,6-dichloro-[4]pyridylamine

2,6-dichloro-3-nitropyridin-4-amine

Downstream raw materials:

3-(5-methoxypentyl)-7-(3,4-dichlorobenzylamino)triazolo[4,5-c]pyridine-2-one

Refernces

• 1、 -. "COMBINATION THERAPY COMPRISING A2A/A2B AND PD-1/PD-L1 INHIBITORS". Page/Page column 113. . Retrieved 2021/07/10.
• 2、 -. "PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS". Page/Page column 42; 79. . Retrieved 2020/08/22.